RT info:eu-repo/semantics/doctoralThesis
T1 Sobre infecciones bacterianas y fúngicas asociadas a COVID-19 en la población española
A1 López Herrero, Rocio
A2 Universidad de Valladolid. Escuela de Doctorado
K1 COVID-19
K1 COVID-19
K1 COVID-19
K1 Coinfections
K1 Coinfecciones
K1 Spain
K1 España
K1 32 Ciencias Médicas
AB IntroductionThe infection caused by the SARS-CoV-2 is a public health issue. Since December 2019, it has resulted in more than 500 million infections and over 6 million deaths worldwide. Spain is one of the most affected countries in the European Union, where COVID-19 infection has led to over 13 million cases and a total of 121,724 deaths as of July 10, 2023. Bacterial and fungal superinfections are a common complication in patients with SARS-CoV-2 infection. The occurrence of such coinfections increases the mortality and morbidity of these patients. It is essential to recognize these types of infections early in order to provide appropriate treatment and reduce the number of secondary complications.The objective of this study was to conduct an epidemiological analysis of bacterial and fungal coinfections in COVID-19-infected patients in the Spanish population using a clinical and administrative database obtained from the Spanish Minimum Basic Data Set (CMBD).Materials and MethodsA retrospective analysis was conducted, encompassing all cases of COVID-19 hospitalizations recorded during the years 2020 and 2021. The data used were obtained from the records of the Spanish National Hospital Data Surveillance System's Minimum Basic Data Set, provided by the Ministry of Health, with a two-year delay in publication. A logistic regression model was used to assess the risk of developing healthcare-associated bacterial and/or fungal coinfection, as well as the risk of in-hospital mortality and Intensive Care Unit (ICU) mortality in patients with coinfection.ResultsThe incidence of bacterial coinfection in hospitalized COVID-19 patients was 2.30%, and fungal coinfection was 1.41%. Coinfections were associated with worse outcomes, including longer hospital stays and higher mortality rates. Gram-negative bacteria, Candida, and Aspergillus were the main causes of infections. The primary risk factors associated with bacterial coinfection were age between 60-79 years, male sex, obesity, chronic obstructive pulmonary disease (COPD), and diabetes. For fungal coinfection, the main risk factors were the presence of sepsis, surgery, age, male sex, COPD, and obesity.ConclusionsCoinfections are not as common as those associated with other viral coinfections. Early detection of coinfection should be conducted, taking into account the primary associated risk factors, in order to prescribe antimicrobial therapy promptly and as indicated, thereby reducing the emergence of antimicrobial resistance.
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/66295
UL https://uvadoc.uva.es/handle/10324/66295
LA spa
NO Escuela de Doctorado
DS UVaDOC
RD 27-jul-2024