RT info:eu-repo/semantics/article
T1 Altered gamma band noise power in schizophrenia and bipolar patients during a cognitive task
A1 Cea-Cañas, Benjamín
A1 Díez, Álvaro
A1 Lubeiro, Alba
A1 Iglesias, María
A1 Capella, Carmen
A1 Rodríguez-Lorenzana, Alberto
A1 Molina, Vicente
AB Background and Objectives“Noise power” (NP) is a measure that allows the assessment of the fast-firing synchronization of neural oscillations. We aimed to replicate higher gamma NP values in frontal and midline regions in patients with schizophrenia and re-evaluate its specificity to this disorder. We also aimed to assess the relationship of higher gamma NP values with drug treatment, chronicity, cognition and symptoms.MethodsGamma NP values were obtained from electroencephalograms recorded during an oddball paradigm from 29 patients with schizophrenia, 27 with bipolar disorder and 36 healthy controls. We compared these values between the groups to evaluate the specificity to diagnosis. Altered gamma NP values were compared between the patients who had and had not received different treatments to assess the relationship with drug treatment. We also analyse the correlation between gamma NP values and chronicity, symptoms, and cognition.ResultsCompared to controls, patients with schizophrenia presented increased gamma NP values in frontal and parietal midline regions, while bipolar patients showed increased gamma NP in the left frontal region. There was no significant relationship between drug treatment or chronicity with altered values. Increased gamma NP correlated with higher negative symptom scores in the schizophrenia group, but not with cognitive impairment in any of the groups of patients.ConclusionsWe replicated an increase in gamma NP in patients with schizophrenia and found that this alteration was also present in a milder form in bipolar patients. These alterations seem to be independent of pharmacological treatment and illness duration.
SN 0213-6163
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/66442
UL https://uvadoc.uva.es/handle/10324/66442
LA spa
NO European Journal of Psychiatry 35 (3): 129-139
DS UVaDOC
RD 11-jul-2024