RT info:eu-repo/semantics/article
T1 Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders
A1 Calafato, Maria Stella
A1 Thygesen, Johan H.
A1 Ranlund, Siri
A1 Zartaloudi, Eirini
A1 Cahn, Wiepke
A1 Crespo-Facorro, Benedicto
A1 Díez-Revuelta, Álvaro
A1 Forti, Marta Di
A1 Hall, Mei-Hua
A1 Iyegbe, Conrad
A1 Jablensky, Assen
A1 Kahn, Rene
A1 Kalaydjieva, Luba
A1 Kravariti, Eugenia
A1 Lin, Kuang
A1 McDonald, Colm
A1 McIntosh, Andrew M.
A1 McQuillin, Andrew
A1 Picchioni, Marco
A1 Rujescu, Dan
A1 Shaikh, Madiha
A1 Toulopoulou, Timothea
A1 Os, Jim Van
A1 Vassos, Evangelos
A1 Walshe, Muriel
A1 Powell, John
A1 Lewis, Cathryn M.
A1 Murray, Robin M.
A1 Bramon, Elvira
AB Background: There is increasing evidence for shared genetic susceptibility between schizophrenia and bipolar disorder. Although genetic variants only convey subtle increases in risk individually, their combination into a polygenic risk score constitutes a strong disease predictor.AimsTo investigate whether schizophrenia and bipolar disorder polygenic risk scores can distinguish people with broadly defined psychosis and their unaffected relatives from controls.Method: Using the latest Psychiatric Genomics Consortium data, we calculated schizophrenia and bipolar disorder polygenic risk scores for 1168 people with psychosis, 552 unaffected relatives and 1472 controls.Results: Patients with broadly defined psychosis had dramatic increases in schizophrenia and bipolar polygenic risk scores, as did their relatives, albeit to a lesser degree. However, the accuracy of predictive models was modest.Conclusions: Although polygenic risk scores are not ready for clinical use, it is hoped that as they are refined they could help towards risk reduction advice and early interventions for psychosis.Declaration of interestR.M.M. has received honoraria for lectures from Janssen, Lundbeck, Lilly, Otsuka and Sunovian.
SN 0007-1250
YR 2018
FD 2018
LK https://uvadoc.uva.es/handle/10324/66448
UL https://uvadoc.uva.es/handle/10324/66448
LA spa
NO British Journal of Psychiatry 213(3): 535-541
DS UVaDOC
RD 18-nov-2024