RT info:eu-repo/semantics/article
T1 Cognitive outcome and gamma noise power unrelated to neuregulin 1 and 3 variation in schizophrenia
A1 Díez, Álvaro
A1 Cieza-Borrella, Clara
A1 Suazo, Vanessa
A1 González Sarmiento, Rogelio
A1 Papiol, Sergi
A1 Molina, Vicente
AB BackgroundNeuregulins are a family of signalling proteins that orchestrate a broad range of cellular responses. Four genes encoding Neuregulins 1–4 have been identified so far in vertebrates. Among them, Neuregulin 1 and Neuregulin 3 have been reported to contribute to an increased risk for developing schizophrenia. We hypothesized that three specific variants of these genes (rs6994992 and rs3924999 for Neuregulin 1 and rs10748842 for Neuregulin 3) that have been related to this illness may modify information processing capacity in the cortex, which would be reflected in electrophysiological parameters (P3b amplitude or gamma noise power) and/or cognitive performance.MethodsWe obtained DNA from 31 patients with schizophrenia and 23 healthy controls and analyzed NRG1 rs6994992, NRG1 rs3924999 and NRG3 rs10748842 promoter polymorphisms by allelic discrimination with real-time polymerase chain reaction (PCR). We compared cognitive outcome, P300 amplitude parameters and an electroencephalographic measure of noise power in the gamma band between the groups dichotomized according to genotype.ResultsContrary to our hypothesis, we could not detect any significant influence of variation in Neuregulin 1/Neuregulin 3 polymorphisms on cognitive performance or electrophysiological parameters of patients with schizophrenia.ConclusionsDespite our findings, we cannot discard that other genetic variants and, more likely, interactions between those variants and with genetic variation related to different pathways may still influence cerebral processing in schizophrenia.
YR 2014
FD 2014
LK https://uvadoc.uva.es/handle/10324/66450
UL https://uvadoc.uva.es/handle/10324/66450
LA spa
NO Annals of General Psychiatry 13(18):1-8
DS UVaDOC
RD 24-nov-2024