RT info:eu-repo/semantics/article
T1 Neurobiological underpinnings of cognitive subtypes in psychoses: A cross-diagnostic cluster analysis
A1 Fernández Linsenbarth, Ines
A1 Planchuelo Gómez, Álvaro
A1 Díez Revuelta, Álvaro
A1 Arjona Valladares, Antonio
A1 Luis García, Rodrigo de
A1 Martín Santiago, Óscar
A1 Benito Sánchez, José Antonio
A1 Pérez Laureano, Ángela
A1 González Parra, David
A1 Montes Gonzalo, Carmen
A1 Melero Lerma, Raquel
A1 Morante, Sonia Fernández
A1 Sanz Fuentenebro, Javier
A1 Gómez Pilar, Javier
A1 Núñez Novo, Pablo
A1 Molina Rodríguez, Vicente
K1 Cognition
K1 Schizophrenia
K1 Bipolar disorder
K1 Connectivity
K1 Modulation
K1 Volume
AB Schizophrenia and bipolar disorder include patients with different characteristics, which may hamper the definition of biomarkers. One of the dimensions with greater heterogeneity among these patients is cognition. Recent studies support the identification of different patients' subgroups along the cognitive domain using cluster analysis. Our aim was to validate clusters defined on the basis of patients' cognitive status and to assess its relation with demographic, clinical and biological measurements. We hypothesized that subgroups characterized by different cognitive profiles would show differences in an array of biological data. Cognitive data from 198 patients (127 with chronic schizophrenia, 42 first episodes of schizophrenia and 29 bipolar patients) were analyzed by a K-means cluster approach and were compared on several clinical and biological variables. We also included 155 healthy controls for further comparisons. A two-cluster solution was selected, including a severely impaired group and a moderately impaired group. The severely impaired group was associated with higher illness duration and symptoms scores, lower thalamus and hippocampus volume, lower frontal connectivity and basal hypersynchrony in comparison to controls and the moderately impaired group. Moreover, both patients' groups showed lower cortical thickness and smaller functional connectivity modulation than healthy controls. This study supports the existence of different cognitive subgroups within the psychoses with different neurobiological underpinnings.
PB Elsevier
SN 0920-9964
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/66451
UL https://uvadoc.uva.es/handle/10324/66451
LA eng
NO Schizophrenia Research, 2021, vol. 229, p. 102-111
NO Producción Científica
DS UVaDOC
RD 05-feb-2025