RT info:eu-repo/semantics/article
T1 Frontal gamma noise power and cognitive domains in schizophrenia
A1 Díez, Álvaro
A1 Suazo, Vanessa
A1 Casado, Pilar
A1 Martín-Loeches, Manuel
A1 Perea, María Victoria
A1 Molina, Vicente
AB The cognitive deficit profile is different among individuals with schizophrenia. We quantified the amount of electroencephalographic activity unlocked to stimuli onset (noise power) over frontal regions regarding deficit in cognitive domains. Forty-six patients with schizophrenia and 27 healthy controls underwent clinical, cognitive and electrophysiological assessments. Noise power studies may be considered complementary but not equivalent to induced power studies. We compared gamma and theta noise power magnitude during a P300 paradigm between subsets of patients divided according to cognitive deficit in key domains and controls. Patients displayed higher gamma noise power activity at Fz site and significantly lower performance in all cognitive domains when compared to controls. The subset of patients with cognitive deficit for working memory and problem solving/executive functions domains displayed significantly higher frontal-lateral noise power values in comparison to the subset of patients without cognitive deficit and controls. Patients with significant cognitive deficits in domains with greater frontal contribution are also characterized by an abnormally higher gamma band noise power over the frontal region. Our data may endorse various biological subsets within schizophrenia, characterized by the presence or absence of a significant cognitive deficit in frontal domains.
SN 0925-4927
YR 2014
FD 2014
LK https://uvadoc.uva.es/handle/10324/66462
UL https://uvadoc.uva.es/handle/10324/66462
LA spa
NO Psychiatry Research: Neuroimaging 221(1):104-13
DS UVaDOC
RD 07-ago-2024