RT info:eu-repo/semantics/article
T1 Usefulness of preoperative determination of serum MR-proadrenomedullin levels to predict the need for postoperative organ support in abdominal oncological surgery
A1 Ramasco Rueda, Fernando
A1 Planas Roca, Antonio
A1 Méndez Hernández, Rosa
A1 Figuerola Tejerina, Angels
A1 Tamayo Gómez, Eduardo
A1 Garcia Bernedo, Carlos
A1 Maseda Garrido, Emilio
A1 Pascual Gómez, Natalia F.
A1 Varga Martínez, Olga de la
K1 Biomarkers
K1 Preoperative care
K1 Postoperative care
K1 Oncology
K1 Abdominal surgery
K1 Surgical oncology
K1 Surgery - Risk factors
K1 MR-proADM
K1 Prodrenomedullin
K1 Organic support
K1 3201.01 Oncología
K1 3213.01 Cirugía Abdominal
K1 32 Ciencias Médicas
AB The need for postoperative organic support is associated with patient outcomes. Biomarkers may be useful for detecting patients at risk. MR-ProADM is a novel biomarker with an interesting profile that can be used in this context. The main objective of this study was to verify whether there was an association between the preoperative serum levels of MR-ProADM and the need for organic support after elective abdominal cancer surgery, and to determine the preoperative MR-ProADM value that predicts the need for postoperative organic support. This was a multicenter prospective observational study conducted by four tertiary hospitals in Spain between 2017 and 2018. Plasma samples were collected for the quantification of MR-ProADM from adults who underwent major abdominal surgery during 2017–2018. The primary outcome was the need for organic support in the first seven postoperative days and its association with the preoperative levels of MR-ProADM, and the secondary outcome was the preoperative levels of MR-ProADM in the study population. This study included 370 patients with a mean age of 67.4 ± 12.9 years. Seventeen percent (63 patients) required some postoperative organic support measures in the first week. The mean preoperative value of MR-ProADM in patients who required organic support was 1.16 ± 1.15 nmol/L. The AUC-ROC of the preoperative MR-ProADM values associated with the need for organic support was 0.67 (95% CI: 0.59–0.75). The preoperative MR-ProADM value, which showed the best compromise in sensitivity and specificity for predicting the need for organic support, was 0.70 nmol/L. The negative predictive value was 91%. A multivariate analysis confirmed that a preoperative level of MR-ProADM ≥ 0.70 nmol/L is an independent factor associated with risk of postoperative organic support (OR 2, 6). Elevated preoperative MR-ProADM levels are associated with the need for postoperative organic support. Therefore, MR-ProADM may be a useful biomarker for perioperative risk assessment.
PB MDPI
SN 2075-4426
YR 2023
FD 2023
LK https://uvadoc.uva.es/handle/10324/66549
UL https://uvadoc.uva.es/handle/10324/66549
LA eng
NO Journal of Personalized Medicine, 2023, Vol. 13, Nº. 7, 1151
NO Producción Científica
DS UVaDOC
RD 11-jul-2024