RT info:eu-repo/semantics/doctoralThesis
T1 Estudio de polimorfismos de VEGFA, VEGFR2, endotelina, endoglina y enos en la hemorragia subaracnoidea espontánea y su relación con los aneurismas cerebrales
A1 Jiménez Arribas, Paloma
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Neurology
K1 Intracranial aneurysm
K1 Aneurisma intracraneal
K1 Subarachnoid hemorrhage
K1 Hemorragia subaracnoidea
K1 Polymorphism
K1 Polimorfismo
K1 Nitric oxide synthase
K1 Óxido nitrico sintasa
K1 3205.0 Neurología
AB Intracranial aneurysms and their rupture are a major health problem in our environment. One third of patients die from hemorrhage and another third have severe permanent disability. Genetic factors are crucial in the formation and clinical evolution of aneurysms. Multiple loci have been associated with the development of intracranial aneurysms, many of them involve multiple pathways related to the maintenance of vascular endothelium and extracellular matrix integrity. The objective of our study is to characterize whether polymorphisms in genes involved in the maintenance of the vascular endothelium could modify the risk of developing aneurysms, presenting a subarachnoid hemorrhage and its clinical complications.
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/66840
UL https://uvadoc.uva.es/handle/10324/66840
LA spa
NO Escuela de Doctorado
DS UVaDOC
RD 12-nov-2024