RT info:eu-repo/semantics/doctoralThesis
T1 Influencia del E-CSF en la aportación de precursores neurales de la zona subependimaria al giro dentado de hipocampo en el ratón adulto
A1 Madrigal Fernández, Miguel Ángel
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Anatomía
K1 Hippocampus
K1 Hipocampo
K1 Cerebrospinal Fluid
K1 Líquido cefalorraquídeo
K1 Neural Precursors
K1 Precursores neurales
K1 Neurogenesis
K1 Neurogénesis
K1 32 Ciencias Médicas
AB The adult mouse hippocampal neurogenic niche is a complex structure which is not completely understood. It hasmainly been related to the Subgranular layer of the dentate gyrus; however, as a result of differential neural stemcell populations reported in the subventricular zone of the lateral ventricle and associated with the hippocampus,the possibility remains of a multifocal niche reproducing developmental stages. Here, using a set of molecularmarkers for neural precursors, we describe in the adult mouse brain hippocampus the existence of a dispersepopulation of neural precursors in the Subependymal Zone, the Dentate Migratory Stream and the hilus; thesedisplay dynamic behaviour compatible with neurogenesis. This supports the idea that the adult hippocampalniche cannot be restricted to the dentate gyrus subgranular layer. In other neurogenic niches such as the SubventricularZone, a functional periventricular dependence has been shown due to the ability to respond toembryonic cerebro-spinal fluid. In this study, we demonstrate that neural precursors from the three areas studied(Sub-ependymal Zone, Dentate Migratory Stream and hilus) are able to modify their behaviour by increasingneurogenesis in a locally differential manner. Our results are compatible with the persistence in the adult mousehippocampus of a neurogenic niche with the same spatial structure as that seen during development and earlypostnatal stages.
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/66896
UL https://uvadoc.uva.es/handle/10324/66896
LA spa
NO Escuela de Doctorado
DS UVaDOC
RD 06-oct-2024