RT info:eu-repo/semantics/doctoralThesis
T1 Nanotransportadores con aplicaciones en Ingeniería de Biosistemas
A1 Santiago Aliste, Alberto
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Cultivos - Protección
K1 Encapsulation
K1 Encapsulación
K1 Nanocarriers
K1 Nanotransportadores
K1 Bioactive natural products
K1 Productos naturales bioactivos
K1 Chitosan
K1 Quitosano
K1 31 Ciencias Agrarias
AB Disease control in agriculture is a growing challenge, due to the appearance of resistances and the prohibition of phytosanitary products, with important repercussions for both farmers and the environment. This PhD Thesis focuses on the search for alternatives for the integrated control of phytopath ogens based on nanotechnology, as a means for the optimization of other integrated management methods. Since natural extracts generally present problems of lability, solubility, and/or lack of specificity, the use of nanocarriers for their delivery and con trolled release is proposed. The improved efficacy of these bioactive products of natural origin with antimicrobial properties when encapsulated in the developed nanocarriers, based on chitosan oligomers and methacrylic anhydride as a crosslinking agent (in conjunction with lignin, graphene carbon nitride, and/or hydroxyapatite), has been evaluated in vitro, ex-situ, and in the field. The selected approach has proven to be suitable for the control of grapevine wood diseases, both for the reduction of vascular necrosis via endotherapy and for the protection of pruning wounds via direct application, and of post-harvest diseases in fruit via surface coating. Encapsulation of therapeutic agents has led to lower inhibitory concentrations than those of unencapsulated extracts in all cases, comparable to those of synthetic fungicides. Additionally, the incorporation of carbon nitride into the nanocarriers allows their multifunctionality, extending their scope of application to environmental remediation.
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/66921
UL https://uvadoc.uva.es/handle/10324/66921
LA spa
NO Escuela de Doctorado
DS UVaDOC
RD 18-nov-2024