RT info:eu-repo/semantics/article
T1 Potentiation by cyclooxygenase inhibitors of the release of catecholamines from the rabbit carotid body and its reversal by prostaglandin E2
A1 Gómez Niño, María Ángeles
A1 Almaraz Gómez, Laura
A1 González, Constancio
K1 Artritis reumatoide - Tratamiento
AB Salicylates, at the high therapeutic doses used in the treatment of rheumatoid arthritis, produce an increase in ventilation and augment the carotidbody reactivity to hypoxic stimulus, leading to an exaggerated hyperventilation during hypoxia. These effects had been related to the action ofsalicylates as uncouplers of oxidative phosphorylation. In the present study, carried out in an in vitro preparation of the rabbit carotid body, we showthat acetylsalicylic acid and indomethacin, two anti-inflammatory drugs that are also powerful inhibitors of cyclooxygenase, the prostaglandinsynthetizingenzyme, produce an increase in the [3H]catecholamine release evoked by low oxygen stimulation. The drugs did not affect basal normoxicrelease, a finding that suggests that at the concentration used these anti-inflammatory agents do not have uncoupling actions, and that their effectson hypoxic-induced release of [3H]catecholamines is mediated by their specific action as cyclooxygenase inhibitors. In agreement with this suggestionwe found that prostaglandin E~ completely prevented the effects of both anti-inflammatory agents. In addition, our data indicate that endogenouslysynt hetized prostaglandins are powerful modulators of chemoreceptor cell function.
PB Elsevier
SN 0304-3940
YR 1992
FD 1992
LK http://uvadoc.uva.es/handle/10324/6716
UL http://uvadoc.uva.es/handle/10324/6716
LA eng
NO Neuroscience Letters, 1992, vol. 140 p.1-4
NO Producción Científica
DS UVaDOC
RD 18-nov-2024