RT info:eu-repo/semantics/article T1 Safety, efficacy, and visual performance of an orthokeratology lens with increased compression factor A1 Martínez Plaza, Elena A1 Zamora Castro, Cecilia A1 Molina Martín, Ainhoa A1 Piñero, David P. K1 Orthokeratology K1 Contact lenses K1 Ophthalmology K1 Lentes de contacto K1 Eye - Diseases - Treatment K1 Ojo - Enfermedades y defectos - Tratamiento K1 Optometry K1 Performance K1 Rendimiento K1 Medicine K1 Medical technology K1 3201.09 Oftalmología K1 2209.15 Optometría K1 3201 Ciencias Clínicas K1 3314 Tecnología Médica AB The aim was to evaluate the safety, efficacy, and visual performance of an orthokeratology lens with an increased compression factor (ICF) of 1.25 D in a 3-month follow-up. Thirty-six myopic patients (5 males and 31 females; 24.2 ± 5.8 years) were fitted with Alexa AR (Tiedra Farmacéutica S.L., Madrid, Spain) contact lenses (CLs) and twenty participants finished the follow-up. Visual acuity (VA), subjective refraction, primary spherical and primary coma aberrations, keratometry, central pachymetry, and ocular surface evaluation were performed at baseline and after 1 night, 1 week, 1 month, and 3 months of CL wear. The differences among visits were analyzed using a repeated-measures analysis of variance or the Friedman test. The spherical equivalent decreased (p ≤ 0.005), and the uncorrected VA improved (p < 0.001) until the first week. Corneal and ocular aberrations showed a significant increase (p ≤ 0.02). A significant decrease (p < 0.001) was found for keratometry values. No significant changes were observed in either central pachymetry or ocular surface parameters among study visits. In conclusion, an orthokeratology CL with an ICF of 1.25 D provides good safety, efficacy, and visual performance in a 3-month follow-up. Seven days of orthokeratology wear are enough to achieve the full myopic compensation, resulting in satisfactory VA. PB MDPI SN 2077-0383 YR 2024 FD 2024 LK https://uvadoc.uva.es/handle/10324/67318 UL https://uvadoc.uva.es/handle/10324/67318 LA eng NO Journal of Clinical Medicine, 2024, Vol. 13, Nº. 2, 587 NO Producción Científica DS UVaDOC RD 17-jun-2024