RT info:eu-repo/semantics/article
T1 Impact of melatonin supplementation on sports performance and circulating biomarkers in highly trained athletes: A systematic review of randomized controlled trials
A1 Celorrio San Miguel, Ana M.
A1 Roche Collado, Enrique
A1 Herranz López, María
A1 Celorrio San Miguel, Marta
A1 Mielgo Ayuso, Juan Francisco
A1 Fernández Lázaro, Diego
K1 Melatonin
K1 Melatonina
K1 Athletes - Nutrition
K1 Deportistas - Alimentación
K1 Supplementation
K1 Suplementos nutritivos
K1 Nutrition
K1 Sports - Physiological aspects
K1 Performance
K1 Entrenamiento (Deportes)
K1 Oxidative stress
K1 Estrés oxidativo
K1 Antioxidants
K1 Antioxidantes
K1 Biomarkers
K1 Health
K1 3206 Ciencias de la Nutrición
K1 3206.08 Nutrientes
K1 3309 Tecnología de Los Alimentos
K1 3309.03 Antioxidantes en Los Alimentos
K1 2411.06 Fisiología del Ejercicio
AB Melatonin (N-acetyl-5 methoxytryptamine) is an indolic neurohormone that modulates a variety of physiological functions due to its antioxidant, anti-inflammatory, and immunoregulatory properties. Therefore, the purpose of this study was to critically review the effects of melatonin supplementation in sports performance and circulating biomarkers related to the health status of highly trained athletes. Data were obtained by performing searches in the following three bibliography databases: Web of Science, PubMed, and Scopus. The terms used were “Highly Trained Athletes”, “Melatonin”, and “Sports Performance”, “Health Biomarkers” using “Humans” as a filter. The search update was carried out in February 2024 from original articles published with a controlled trial design. The PRISMA rules, the modified McMaster critical review form for quantitative studies, the PEDro scale, and the Cochrane risk of bias were applied. According to the inclusion and exclusion criteria, 21 articles were selected out of 294 references. The dose of melatonin supplemented in the trials ranged between 5 mg to 100 mg administered before or after exercise. The outcomes showed improvements in antioxidant status and inflammatory response and reversed liver damage and muscle damage. Moderate effects on modulating glycemia, total cholesterol, triglycerides, and creatinine were reported. Promising data were found regarding the potential benefits of melatonin in hematological biomarkers, hormonal responses, and sports performance. Therefore, the true efficiency of melatonin to directly improve sports performance remains to be assessed. Nevertheless, an indirect effect of melatonin supplementation in sports performance could be evaluated through improvements in health biomarkers.
PB MDPI
SN 2072-6643
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/67368
UL https://uvadoc.uva.es/handle/10324/67368
LA eng
NO Nutrients, 2024, Vol. 16, Nº. 7, 1011
NO Producción Científica
DS UVaDOC
RD 11-jul-2024