RT info:eu-repo/semantics/article
T1 Biological rhythms, chrono-nutrition, and gut microbiota: Epigenomics insights for precision nutrition and metabolic health
A1 de Oliveira Melo, Nathalia Caroline
A1 Cuevas Sierra, Amanda
A1 Souto, Vitória Felício
A1 Martínez Hernández, José Alfredo
K1 Circadian rhythms
K1 Genomics
K1 Nutrition
K1 Biological rhythms
K1 Ritmos biológicos
K1 Biological Clocks - Physiology
K1 Genomics
K1 Genómica
K1 Genetics
K1 Genética humana
K1 Environmental adaptation
K1 Microbiota
K1 Gut microbiota
K1 Microbiota intestinal
K1 Nutrition
K1 Metabolism
K1 Metabolismo
K1 Public health
K1 3206 Ciencias de la Nutrición
K1 32 Ciencias Médicas
K1 3212 Salud Publica
AB Circadian rhythms integrate a finely tuned network of biological processes recurring every 24 h, intricately coordinating the machinery of all cells. This self-regulating system plays a pivotal role in synchronizing physiological and behavioral responses, ensuring an adaptive metabolism within the environmental milieu, including dietary and physical activity habits. The systemic integration of circadian homeostasis involves a balance of biological rhythms, each synchronically linked to the central circadian clock. Central to this orchestration is the temporal dimension of nutrient and food intake, an aspect closely interwoven with the neuroendocrine circuit, gut physiology, and resident microbiota. Indeed, the timing of meals exerts a profound influence on cell cycle regulation through genomic and epigenetic processes, particularly those involving gene expression, DNA methylation and repair, and non-coding RNA activity. These (epi)genomic interactions involve a dynamic interface between circadian rhythms, nutrition, and the gut microbiota, shaping the metabolic and immune landscape of the host. This research endeavors to illustrate the intricate (epi)genetic interplay that modulates the synchronization of circadian rhythms, nutritional signaling, and the gut microbiota, unravelling the repercussions on metabolic health while suggesting the potential benefits of feed circadian realignment as a non-invasive therapeutic strategy for systemic metabolic modulation via gut microbiota. This exploration delves into the interconnections that underscore the significance of temporal eating patterns, offering insights regarding circadian rhythms, gut microbiota, and chrono-nutrition interactions with (epi)genomic phenomena, thereby influencing diverse aspects of metabolic, well-being, and quality of life outcomes.
PB MDPI
SN 2218-273X
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/67670
UL https://uvadoc.uva.es/handle/10324/67670
LA eng
NO Biomolecules, 2024, Vol. 14, Nº. 5, 559
NO Producción Científica
DS UVaDOC
RD 12-jul-2024