RT info:eu-repo/semantics/article
T1 Genetic architecture of ischaemic strokes after COVID-19 shows similarities with large vessel strokes
A1 Llucià Carol, Laia
A1 Muiño, Elena
A1 Cullell, Natalia
A1 Cárcel Márquez, Jara
A1 Lledós, Miquel
A1 Gallego Fabrega, Cristina
A1 Martin Campos, Jesús
A1 Martí Fàbregas, Joan
A1 Aguilera Simón, Ana
A1 Planas, Anna
A1 DeDiego, Marta L.
A1 Felipe Mimbrera, Alicia de
A1 Masjuan, Jaime
A1 García Madrona, Sebastián
A1 Segura, Tomás
A1 González Villar, Esther
A1 Serrano Heras, Gemma
A1 Domínguez Mayoral, Ana
A1 Menéndez Valladares, Paloma
A1 Montaner, Joan
A1 Migeotte, Isabelle
A1 Rahmouni, Souad
A1 Darcis, Gilles
A1 Bernardo Ordiz, David
A1 Rojo Rello, Silvia
A1 Schulte, Eva Christina
A1 Protzer, Ulrike
A1 Fricke, Lisa
A1 Winter, Christof
A1 Niemi, Mari
A1 Cordioli, Mattia
A1 Delgado, Pilar
A1 Fernández Cadenas, Israel
K1 COVID-19
K1 Ischaemic stroke
K1 GWAS
K1 Local genetic correlation
K1 PRS
K1 32 Ciencias Médicas
K1 3205.05 Enfermedades Infecciosas
K1 3205.01 Cardiología
K1 3205.07 Neurología
AB We aimed to analyse whether patients with ischaemic stroke (IS) occurring within eight days after the onset of COVID-19 (IS-COV) are associated with a specific aetiology of IS. We used SUPERGNOVA to identify genome regions that correlate between the IS-COV cohort (73 IS-COV cases vs. 701 population controls) and different aetiological subtypes. Polygenic risk scores (PRSs) for each subtype were generated and tested in the IS-COV cohort using PRSice-2 and PLINK to find genetic associations. Both analyses used the IS-COV cohort and GWAS from MEGASTROKE (67,162 stroke patients vs. 454,450 population controls), GIGASTROKE (110,182 vs. 1,503,898), and the NINDS Stroke Genetics Network (16,851 vs. 32,473). Three genomic regions were associated (p-value < 0.05) with large artery atherosclerosis (LAA) and cardioembolic stroke (CES). We found four loci targeting the genes PITX2 (rs10033464, IS-COV beta = 0.04, p-value = 2.3 × 10−2, se = 0.02), previously associated with CES, HS6ST1 (rs4662630, IS-COV beta = −0.04, p-value = 1.3 × 10−3, se = 0.01), TMEM132E (rs12941838 IS-COV beta = 0.05, p-value = 3.6 × 10−4, se = 0.01), and RFFL (rs797989 IS-COV beta = 0.03, p-value = 1.0 × 10−2, se = 0.01). A statistically significant PRS was observed for LAA. Our results suggest that IS-COV cases are genetically similar to LAA and CES subtypes. Larger cohorts are needed to assess if the genetic factors in IS-COV cases are shared with the general population or specific to viral infection.
PB MDPI
SN 1422-0067
YR 2023
FD 2023
LK https://uvadoc.uva.es/handle/10324/67705
UL https://uvadoc.uva.es/handle/10324/67705
LA eng
NO International Journal of Molecular Sciences, 2023, Vol. 24, Nº. 17, 13452
NO Producción Científica
DS UVaDOC
RD 24-nov-2024