RT info:eu-repo/semantics/article T1 Prehospital targeting of 1-year mortality in acute chest pain by cardiac biomarkers A1 Zalama Sánchez, Daniel A1 Martín Rodríguez, Francisco A1 López Izquierdo, Raúl A1 Delgado Benito, Juan F. A1 Sánchez Soberón, Irene A1 Pozo Vegas, Carlos del A1 Sanz García, Ancor K1 Emergency medicine K1 Medicina de urgencia K1 Cardiology K1 Chest pain K1 Coronary heart disease - Diagnosis K1 Enfermedad coronaria - Tratamiento K1 Mortality K1 Mortalidad K1 Heart - Diseases K1 Corazón, Enfermedades K1 Biochemical markers - Diagnostic use K1 Public health K1 3205.01 Cardiología K1 32 Ciencias Médicas K1 3212 Salud Publica AB The identification and appropriate management of patients at risk of suffering from acute chest pain (ACP) in prehospital care are not straightforward. This task could benefit, as occurs in emergency departments (EDs), from cardiac enzyme assessment. The aim of the present work was to derive and validate a scoring system based on troponin T (cTnT), N-terminal pro B-type natriuretic peptide (NT-proBNP), and D-dimer to predict 1-year mortality in patients with ACP. This was a prospective, multicenter, ambulance-based cohort study of adult patients with a prehospital ACP diagnosis who were evacuated by ambulance to the ED between October 2019 and July 2021. The primary outcome was 365-day cumulative mortality. A total of 496 patients fulfilled the inclusion criteria. The mortality rate was 12.1% (60 patients). The scores derived from cTnT, NT-proBNP, and D-dimer presented an AUC of 0.802 (95% CI: 0718-0.886) for 365-day mortality. This AUC was superior to that of each individual cardiac enzyme. Our study provides promising evidence for the predictive value of a risk score based on cTnT, NT-proBNP, and D-dimer for the prediction of 1-year mortality in patients with ACP. The implementation of this score has the potential to benefit emergency medical service care and facilitate the on-scene decision-making process. PB MDPI SN 2075-4418 YR 2023 FD 2023 LK https://uvadoc.uva.es/handle/10324/67970 UL https://uvadoc.uva.es/handle/10324/67970 LA eng NO Diagnostics, 2023, Vol. 13, Nº. 24, 3681 NO Producción Científica DS UVaDOC RD 13-nov-2024