RT info:eu-repo/semantics/article
T1 Prehospital targeting of 1-year mortality in acute chest pain by cardiac biomarkers
A1 Zalama Sánchez, Daniel
A1 Martín Rodríguez, Francisco
A1 López Izquierdo, Raúl
A1 Delgado Benito, Juan F.
A1 Sánchez Soberón, Irene
A1 Pozo Vegas, Carlos del
A1 Sanz García, Ancor
K1 Emergency medicine
K1 Medicina de urgencia
K1 Cardiology
K1 Chest pain
K1 Coronary heart disease - Diagnosis
K1 Enfermedad coronaria - Tratamiento
K1 Mortality
K1 Mortalidad
K1 Heart - Diseases
K1 Corazón, Enfermedades
K1 Biochemical markers - Diagnostic use
K1 Public health
K1 3205.01 Cardiología
K1 32 Ciencias Médicas
K1 3212 Salud Publica
AB The identification and appropriate management of patients at risk of suffering from acute chest pain (ACP) in prehospital care are not straightforward. This task could benefit, as occurs in emergency departments (EDs), from cardiac enzyme assessment. The aim of the present work was to derive and validate a scoring system based on troponin T (cTnT), N-terminal pro B-type natriuretic peptide (NT-proBNP), and D-dimer to predict 1-year mortality in patients with ACP. This was a prospective, multicenter, ambulance-based cohort study of adult patients with a prehospital ACP diagnosis who were evacuated by ambulance to the ED between October 2019 and July 2021. The primary outcome was 365-day cumulative mortality. A total of 496 patients fulfilled the inclusion criteria. The mortality rate was 12.1% (60 patients). The scores derived from cTnT, NT-proBNP, and D-dimer presented an AUC of 0.802 (95% CI: 0718-0.886) for 365-day mortality. This AUC was superior to that of each individual cardiac enzyme. Our study provides promising evidence for the predictive value of a risk score based on cTnT, NT-proBNP, and D-dimer for the prediction of 1-year mortality in patients with ACP. The implementation of this score has the potential to benefit emergency medical service care and facilitate the on-scene decision-making process.
PB MDPI
SN 2075-4418
YR 2023
FD 2023
LK https://uvadoc.uva.es/handle/10324/67970
UL https://uvadoc.uva.es/handle/10324/67970
LA eng
NO Diagnostics, 2023, Vol. 13, Nº. 24, 3681
NO Producción Científica
DS UVaDOC
RD 23-nov-2024