RT info:eu-repo/semantics/article
T1 Janus Magnetic‐Plasmonic Nanoparticles for Magnetically Guided and Thermally Activated Cancer Therapy
A1 Espinosa, Ana
A1 Reguera, Javier
A1 Curcio, Alberto
A1 Muñoz‐Noval, Álvaro
A1 Kuttner, Christian
A1 Van de Walle, Aurore
A1 Liz‐Marzán, Luis M.
A1 Wilhelm, Claire
AB Progress of thermal tumor therapies and their translation into clinical practice are limited by insufficient nanoparticle concentration to release therapeutic heating at the tumor site after systemic administration. Herein, the use of Janus magneto-plasmonic nanoparticles, made of gold nanostars and iron oxide nanospheres, as efficient therapeutic nanoheaters whose on-site delivery can be improved by magnetic targeting, is proposed. Single and combined magneto- and photo-thermal heating properties of Janus nanoparticles render them as compelling heating elements, depending on the nanoparticle dose, magnetic lobe size, and milieu conditions. In cancer cells, a much more effective effect is observed for photothermia compared to magnetic hyperthermia, while combination of the two modalities into a magneto-photothermal treatment results in a synergistic cytotoxic effect in vitro. The high potential of the Janus nanoparticles for magnetic guiding confirms them to be excellent nanostructures for in vivo magnetically enhanced photothermal therapy, leading to efficient tumor growth inhibition.
SN 1613-6810
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/68098
UL https://uvadoc.uva.es/handle/10324/68098
LA eng
NO Small, 2020, 16 (11), 1904960
NO Producción Científica
DS UVaDOC
RD 17-jul-2024