RT info:eu-repo/semantics/article
T1 Correlation Between Adenosine Triphosphate Levels, Dopamine Release and Electrical Activity in the Carotid Body: Support for the Metabolic Hypothesis of Chemoreception
A1 Obeso Cáceres, Ana María de la Luz
A1 Almaraz Gómez, Laura
A1 González, Constancio
K1 Neurofisiología
AB An unsolved issue for the arterial chemoreceptors is the mechanism by which hypoxia and other natural stimuli lead to an increase ofactivity in the carotid sinus nerve. According to the 'metabolic hypothesis', the hypoxic activation of the carotid body (CB) is mediatedby a decrease of the ATP levels in the type I cells, which then release a neurotransmitter capable of exciting the sensory nerve endings.Using an in vitro preparation of cat CB, we report that ATP levels in the CB do in fact decrease when the organs are exposed to moderate,short lasting hypoxia (5 min 20% 02). Additionally, we found that decreases in ATP levels induced by 2-deoxyglucose (2 mM) orsodium cyanide (0.1 raM) are closely correlated with dopamine release from type I cells and electrical activity in the carotid sinusnerve elicited by these agents. The possible cause-effect relationship of these events is discussed
PB Elsevier
SN 0006-8993
YR 1985
FD 1985
LK http://uvadoc.uva.es/handle/10324/6842
UL http://uvadoc.uva.es/handle/10324/6842
LA eng
NO Brain Research, 1985, vol. 348, p.64-68
NO Producción Científica
DS UVaDOC
RD 04-dic-2024