RT info:eu-repo/semantics/article
T1 Differential stimulus coupling to dopamine and norepinephrine stores in rabbit carotid body type I cells
A1 Gómez Niño, María Ángeles
A1 Dinger, Bruce
A1 González, Constancio
A1 Fidone, Salvatore
K1 Neurofisiología
AB Recent studies suggest that preneural type I (glomus) cells in the arterial chemoreceptor tissue of the carotid body act as primary transducerelements which respond to natural stimuli (low 02, pH or increased CO2) by releasing chemical transmitter agents capable of exciting the closelyapposed afferent nerve terminals. These type I cells contain multiple putative transmitters, but the identity of the natural excitatory agentsremains an unresolved problem in carotid body physiology. Characterization of putative transmitter involvement in the response to naturaland pharmacological stimuli has therefore become fundamental to further understanding of chemotransmission in this organ. The present studydemonstrates that a natural stimulus (hypoxia) evokes the release of dopamine (DA) and norepinephrine (NE) in approximate proportion totheir unequal stores in rabbit carotid body (DA release/NE release = 8.2). In contrast, nicotine (100/~M), a cholinornimetic agent thoughtto act on the nicotinic receptors present on the type I cells, evokes the preferential release of NE (DA release/NE release = 0.17). Thesefindings suggest that distinct mechanisms are involved in a differential mobilization of these two cateeholamines from the rabbit carotid body.
PB Elsevier
SN 0006-8993
YR 1990
FD 1990
LK http://uvadoc.uva.es/handle/10324/6849
UL http://uvadoc.uva.es/handle/10324/6849
LA eng
NO Brain Research 525(1990) 160-164
DS UVaDOC
RD 24-nov-2024