RT info:eu-repo/semantics/article
T1 Investigating the prognostic role of peripheral inflammatory markers in mild cognitive impairment
A1 Tondo, Giacomo
A1 Aprile, Davide
A1 De Marchi, Fabiola
A1 Sarasso, Barbara
A1 Serra, Paola
A1 Borasio, Giordana
A1 Rojo Martínez, Esther
A1 Arenillas Lara, Juan Francisco
A1 Comi, Cristoforo
K1 Cognition disorders
K1 Mild Cognitive Impairment
K1 Dementia
K1 Demencia
K1 Nervous system - Degeneration
K1 Sistema nervioso - Degeneración
K1 Neurology
K1 Neurology
K1 Neuroimmunology
K1 Neuroinmunología
K1 Inflammation
K1 Inflamación
K1 Clinical medicine
K1 32 Ciencias Médicas
K1 3205.07 Neurología
K1 6104.01 Procesos Cognitivos
AB Growing evidence suggests that neuroinflammation plays a critical role in the pathogenesis of neurodegenerative diseases. Peripheral markers of inflammation, including blood cell counts and their ratios, such as the neutrophil-to-lymphocyte ratio (NLR), have been reported as an easily accessible and reliable proxy of central nervous system inflammation. However, the role of peripheral inflammation in dementia and Mild Cognitive Impairment (MCI) still needs to be clarified. In the current study, we aimed to assess the prognostic role of the NLR and other peripheral markers of inflammation in a sample of 130 amnestic MCI, followed up for two to five years. The Mini-Mental state examination (MMSE) score at baseline and follow-up visits was used to assess global cognitive status at each visit and the degree of cognitive decline over time. Baseline peripheral markers of inflammation included blood cell counts and ratios, specifically the NLR, the platelet-to-lymphocyte ratio (PLR), the monocyte-to-lymphocyte ratio (MLR), and the systemic immune inflammation index (SII). After classifying subjects into CONVERTERS and non-CONVERTERS (respectively, patients converting to dementia and subjects showing stability at the last available follow-up), we compared peripheral markers of inflammation among groups ed correlated them with cognitive measures, testing the ability of significant factors to predict conversion to dementia. In our cohort, CONVERTERS showed lower baseline MMSE scores (p-value = 0.004) than non-CONVERTERS. In addition, CONVERTERS had statistically elevated NLR (p-value = 0.005), PLR (p-value = 0.002), and SII levels (p-value = 0.015), besides a lower number of lymphocytes (p-value = 0.004) compared with non-CONVERTERS. In a logistic regression analysis, baseline MMSE scores and NLR predicted conversion to dementia. Tertiles analysis showed that MCI with the highest NLR values had a higher conversion risk. Our study supports the hypothesis that a dysregulation of peripheral inflammation involving both lymphocytes and neutrophils may play a role in the pathogenesis of dementia, even at the early stages of neurodegeneration, as in the MCI condition.
PB MDPI
SN 2077-0383
YR 2023
FD 2023
LK https://uvadoc.uva.es/handle/10324/68670
UL https://uvadoc.uva.es/handle/10324/68670
LA eng
NO Journal of Clinical Medicine, 2023, Vol. 12, Nº. 13, 4298
NO Producción Científica
DS UVaDOC
RD 11-jul-2024