RT info:eu-repo/semantics/doctoralThesis
T1 Seguimiento neurológico en una cohorte de pacientes con asfixia perinatal
A1 Hortigüela Saeta, María Montesclaros
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Asfixia perinatal
K1 Neurodevelopmental
K1 Neurodesarrolllo
K1 32 Ciencias Médicas
AB Perinatal asphyxia is an injury to the foetus or newborn around the time of delivery due to decreased blood oxygenation and/or lack of adequate tissue perfusion. Among the leading causes of death in the neonatal period worldwide, hypoxic ischaemic encephalopathy (HIE) ranks third after infections and preterm birth. In addition, central nervous system damage in the neonatal period contributes to the global burden of disease at a high rate in terms of disability-adjusted life years, years lost and years of life lived with disability. Following the introduction of hypothermia as a treatment for severe moderate hypoxic ischaemic encephalopathy, the long-term neurological sequelae traditionally associated with this condition are decreasing, while new problems are emerging.  In Spain there are no studies that have examined the neurological evolution of these patients in detail after hypothermia implantation. The availability of updated population-based data in our setting on the state of the different areas of neurodevelopment in children with a history of perinatal asphyxia is important for planning follow-up programmes and managing economic resources.The sequelae that can develop in children with hypoxic-ischaemic aggression who develop hypoxic-ischaemic encephalopathy are well known; however, there are fewer studies on the neurological follow-up of patients with asphyxia without encephalopathy. As for infants with mild HIE, most of them will behave like children without encephalopathy in the future, although some of them may develop minor motor problems or develop learning difficulties in school years. Several clinical trials have shown that a reduction of 3-4˚C by body cooling is an effective intervention in children who develop moderate-severe EHI, which in addition to reducing mortality, is able to reduce the degree of disability and neurodevelopmental impairment compared to children who do not receive hypothermia treatment. Recent European studies highlight the shift of severe pathology towards mild motor disorders and emotional problems. The aim of this study is to assess neurodevelopmental disturbances at the age of 3 years in a cohort of children with perinatal asphyxia criteria. These patients were divided into three groups according to severity at birth: perinatal asphyxia without encephalopathy, mild hypoxic ischaemic encephalopathy and moderate and severe hypoxic ischaemic encephalopathy. In addition, controls without perinatal asphyxia were included to better detect the extent of sequelae in each group.
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/68790
UL https://uvadoc.uva.es/handle/10324/68790
LA spa
NO Escuela de Doctorado
DS UVaDOC
RD 16-jul-2024