RT info:eu-repo/semantics/article
T1 Intravitreal stem cell paracrine properties as a potential neuroprotective therapy for retinal photoreceptor neurodegenerative diseases
A1 Fernández Bueno, Iván
A1 Puertas Neyra, Kevin Louis
A1 Usategui Martín, Ricardo
A1 Coco Martín, Rosa María
K1 32 CIENCIAS MEDICAS;  3201: Ciencias clínicas; 320109: Oftalmología
K1 clinical trials; growth factors; intraocular injection; intravitreal injection; neuroprotection; paracrine properties; photoreceptors; preclinical models; retinal diseases; stem cells
K1 3201.09 Oftalmología
AB Abstract: Retinal degenerations are the leading causes of irreversible visual loss worldwide. Many pathologies included under this umbrella involve progressive degeneration and ultimate loss of the photoreceptor cells, with age-related macular degeneration and inherited and ischemic retinal diseases the most relevant. These diseases greatly impact patients’ daily lives, with accompanying marked social and economic consequences. However, the currently available treatments only delay the onset or slow progression of visual impairment, and there are no cures for these photoreceptor diseases. Therefore, new therapeutic strategies are being investigated, such as gene therapy, optogenetics, cell replacement, or cell-based neuroprotection. Specifically, stem cells can secrete neurotrophic, immunomodulatory, and anti-angiogenic factors that potentially protect and preserve retinal cells from neurodegeneration. Further, neuroprotection can be used in different types of retinal degenerative diseases and at different disease stages, unlike other potential therapies. This review summarizes stem cell-based paracrine neuroprotective strategies for photoreceptor degeneration, which are under study in clinical trials, and the latest preclinical studies. Effective retinal neuroprotection could be the next frontier in photoreceptor diseases, and the development of novel neuroprotective strategies will address the unmet therapeutic needs.
PB MDPI
SN 1673-5374
YR 2020
FD 2020-09
LK https://uvadoc.uva.es/handle/10324/68879
UL https://uvadoc.uva.es/handle/10324/68879
LA eng
NO Neural Regen Res, Sep, 2020, vol.15, n. 9, p.1631-1638.
NO Producción Científica
DS UVaDOC
RD 27-jul-2024