RT info:eu-repo/semantics/article
T1 A chronic pain: inflammation-dependent chemoreceptor adaptation in rat carotid body
A1 Liu, X.
A1 He, Le
A1 Dinger, Bruce
A1 González, Constancio
A1 Stensaas, L.
A1 Fidone, Salvatore
K1 Neurofisiología
K1 Dolor crónico - Tratamiento
AB Experiments in recent years have revealed labile electrophysiological and neurochemicalphenotypes in primary afferent neurons exposed to specific stimulus conditions associated withthe development of chronic pain. These studies collectively demonstrate that the mechanismsresponsible for functional plasticity are primarily mediated by novel neuroimmune interactionsinvolving circulating and resident immune cells and their secretory products, which togetherinduce hyperexcitability in the primary sensory neurons. In another peripheral sensory modality,namely the arterial chemoreceptors, sustained stimulation in the form of chronic hypoxia (CH)elicits increased chemoafferent excitability from the mammalian carotid body. Previous studieswhich focused on functional changes in oxygen-sensitive type I cells in this organ have onlypartially elucidated the molecular and cellular mechanisms which initiate and control this adaptiveresponse. Recent studies in our laboratory indicate a unique role for the immune system inregulating the chemo-adaptive response of the carotid body to physiologically relevant levels ofhypoxia.
PB Elsevier
SN 1569-9048
YR 2011
FD 2011
LK http://uvadoc.uva.es/handle/10324/6890
UL http://uvadoc.uva.es/handle/10324/6890
LA eng
NO Respiratry Physiology and Neurobiology : 2011, 178(3) 362-369
NO Producción Científica
DS UVaDOC
RD 23-nov-2024