RT info:eu-repo/semantics/article
T1 Progression of myopic maculopathy in a Caucasian cohort of highly myopic patients with long follow-up: a multistate analysis
A1 Coco Martín, Rosa María
A1 Belani Raju, Minal
A1 de la Fuente-Gómez, Daniel
A1 Sanabria Ruiz Colmenares, María Rosa
A1 Fernández Martínez, Itziar
K1 Choroidal neovascularization; High myopia; Lacquer cracks; Multistate models; Myopic maculopathy; Pathologic myopia; Risk factors of progression
K1 3201.09 Oftalmología
AB ABSTRACT. PURPOSE This study aims to determine the probability of progression of myopic maculopathy according to age. METHODS This is a longitudinal observational study of single-center retrospective cohort of Caucasian patients formed by 212 consecutive adults with high myopia. Main outcome measures were age, visual acuity (VA), refractive error (RE), follow-up time, and the macular status assessed at least 5 years apart according to the Meta-Analysis of Pathologic Myopia Study Group. The progression rate was calculated based on per 1000 eyes/year.Multistate models were fitted to identify the predictive factors and to calculate the most probable age of progression onset using the Aalen–Johansen estimator. RESULTS We studied 220 eyes of 122 Caucasian patients. Mean age was 48.18 ± 14.1, mean follow-up 12.73 ± 5.81 years. One hundred and fifty-two (69.1%) eyes progressed of category, and 96 (44%) worsened a mean of 0.3 logMAR units during followup. The progression rate was 32.21/1000 eyes/year. The probability of progressing increased with age; it was higher in women if there was a family history of myopia, worse VA, higher RE, or wide macular staphyloma. The probability of progressing from category 1 was > 0.6 after 70 years of age; from category 2, it was 0.7 after 70 years; and 0.5 from category 3 after 75 years. If choroidal neovascularization (CNV) appeared, this probability exceeded 0.7 between ages 45 and 55 for all categories. CONCLUSION The progression rate is lower than in a Japanese series. The vision worsened with disease progression, and the probability of both happening increased after the age of 70–75. If CNV appears, the risk of progression is very high at the age of 45–55.
PB Springer Nature
SN 0721-832X
YR 2020
FD 2020-01
LK https://uvadoc.uva.es/handle/10324/68942
UL https://uvadoc.uva.es/handle/10324/68942
LA spa
NO Graefes Arch Clin Exp Ophthalmol, Jan, 2021, vol. 259, n. 1, p. 81-92.
DS UVaDOC
RD 25-jul-2024