RT info:eu-repo/semantics/article
T1 Intraocular toxicity caused by MEROCTANE perfluorocarbon liquid
A1 Coco Martín, Rosa María
A1 Andrés Iglesias, Cristina
A1 Srivastava, Girish Kumar
A1 Lagos-Rodriguez, Javier
A1 Ruiz-Tevah, Miguel
A1 Díaz-Cárdenas, Mario R.
A1 Fernández Bueno, Iván
A1 García Serna, Juan
A1 García Gutiérrez, Maria Teresa
A1 García-Layana, Alfredo
A1 Pastor Jimeno, José Carlos
K1 Translational research, Mass spectrometry, Cell culture, Retina
K1 3201.09 Oftalmología
AB ABSTRACT. Serious intraocular toxicity cases have been reported worldwide after the use of different perfluorocarbon liquids. The current study reports for the first-time the clinical pictures of cases of acute intraocular toxicity caused by Meroctane®, a perfluoro-octane commercialized by a Turkish company and distributed in many countries. A series of 18 cases from Chile and Spain was retrospectively analysed. To evaluate the impurity profile, a suspicious Meroctane® sample (lot OCT.01.2013) was analysed by gas chromatography mass spectrometry and compared with a non-suspicious sample of the same commercial perfluoro-octane (lot OCT 722011). Cytotoxicity was tested following a direct-contact method, taking into consideration the high volatility and hydrophobicity of perfluoro-octane and following the ISO 10993 guideline. Cytotoxicity test showed clear cytotoxic effects of the analysed batch (less than 9% of cell viability). Moreover, chemical analysis demonstrated the presence of many contaminants, some highly toxic (acids and alcohols). Perfluorocarbon liquids are useful tools for intraocular surgery but companies and Agencies of Medical Devices must implement measures that guarantee the safety of these products based on both chemical and cytotoxicity analysis for every batch. Medical staff should be encouraged to report any suspected case to their respective National Agencies.
PB Nature Publishing Group
SN 2045-2322
YR 2021
FD 2021-01-12
LK https://uvadoc.uva.es/handle/10324/68949
UL https://uvadoc.uva.es/handle/10324/68949
LA eng
NO Sci Rep, Jan, 2021, vol. 11; n. 1, Nº artículo 599 (9 páginas).
NO Producción Científica
DS UVaDOC
RD 27-jul-2024