RT info:eu-repo/semantics/article
T1 Silicone microbubbles after anti‐vascular endothelial growth factor injections in patients with wet age‐related macular degeneration: incidence, quantification and secondary optical coherence tomography artfacts
A1 Sanabria Ruiz Colmenares, María Rosa
A1 Alonso Tarancón, Ana María
A1 Calles Monar, Paola Stefanía
A1 Ibañez, Patricia
A1 García de Arriba, Santiago
A1 Alvarez, Nuria
A1 Piñuel, Jesús A.
A1 Coco Martín, Rosa María
A1 Fernández Martínez, Itziar
K1 age-related macular degeneration – intravitreal injections – macular degenerations – OCT artfacts – silicone microbubbles – wet
K1 3201.09 Oftalmología
AB ABSTRACT. PURPOSE: To report the incidence and quantity of silicone oil microbubbles and the relationship with the number of intravitreal anti-vascular endothelial growth factor (VEGF) injections and evaluate if microbubbles induce artefacts on optical coherence tomography (OCT) images. METHODS: Observational, descriptive, cross-sectional study. Patients with wet age-related macular degeneration were included who had been treated for 1 year minimally with anti-VEGF injections repackaged in the hospital pharmacy. Detection and quantification of silicone microbubbles by mydriatic biomicroscopic examination were conducted 1 month after the last injection. The numbers of microbubbles were quantified on a scale of 0–3: 0, none; 1 scarce (1–10 microbubbles); 2 moderate (10–30); or 3 numerous (>30). Shadowing on OCT images was classified as 0–3: 0, none; 1 obscuring some retinal layers; 2 obscuring all retinal layers; or 3 obscuring the retinal thickness. RESULTS: The study included 142 eyes of 98 patients (mean age, 82.4 years + 7.3; range, 65–97) treated with 2377 injections. Microbubbles were detected in 127 (89.4%) eyes, 62 (43.6%) with numerous microbubbles and 36 (25.4%) and 29 (20.4%), respectively, with scarce and moderate numbers. A positive correlation was found between the numbers of injections and intravitreal silicone (rho, 0.7). Optical coherence tomography (OCT) artefacts were detected in 11 eyes; the artefacts obscured all retinal layers in three eyes. No significant relationship could be established between the appearance of floaters and the microbubbles. CONCLUSION: The presence and number of silicone microbubbles were correlated with the number of intravitreal injections. Microbubbles can produce OCT artefacts, which can hinder the treatment decision.
PB Wiley Online Library
SN 1755-375X
YR 2021
FD 2021-11
LK https://uvadoc.uva.es/handle/10324/68951
UL https://uvadoc.uva.es/handle/10324/68951
LA spa
NO Acta Ophthalmol, Nov, 2021, vol. 99, n. 7, p. e1051-e1055.
NO Producción Científica
DS UVaDOC
RD 26-jul-2024