RT info:eu-repo/semantics/doctoralThesis T1 Influencia de los factores medioambientales en la morbimortalidad causada por la infección por SARS-CoV-2 A1 Eiros Bachiller, José María A2 Universidad de Valladolid. Escuela de Doctorado K1 Factores ambientales K1 COVID 19 K1 COVID 19 K1 Environmental factor K1 Factores ambientales K1 32 Ciencias Médicas AB This study analyzed, at a postcode detailed level, the relation-ship between short-term exposure to environmental factors and hospital ad-missions, in-hospital mortality, ICU admission, and ICU mortality due to COVID-19 during the lockdown and post-lockdown 2020 period in Spain.Methods: We performed a nationwide population-based retrospective study on 208,744 patients admitted to Spanish hospitals due to COVID-19 based on the Minimum Basic Data Set (MBDS) during the first two waves of the pandemic in 2020. Environmental data were obtained from Copernicus Atmosphere Monitoring Service. Theassociation was assessed by a generalized additive model.Results: PM2.5 was the most critical environmental factor related to hospital admissions and hospital mortality due to COVID-19 during the lockdown in Spain, PM10, NO2, and SO2and also showed associations. The effect was considerably reduced during the post-lockdown period. ICU admissions in COVID-19 patients were mainlyassociated with PM2.5, PM10, NO2, and SO2 during the lockdown as well. During the lockdown, exposure to PM2.5 and PM10 were the most critical environmental factors related to ICU mortality in COVID-19.Conclusion: Short-term exposure to air pollutants impacts COVID-19 out-comes during the lockdown, especially PM2.5, PM10, NO2, and SO2. These pollutants are associated with hospital admission, hospital mortality and ICU admission, while ICU mortality is mainly associated with PM2.5 and PM10. Our findings reveal the importance of monitoring air pollutants in respiratory infectious diseases. YR 2024 FD 2024 LK https://uvadoc.uva.es/handle/10324/69493 UL https://uvadoc.uva.es/handle/10324/69493 LA spa NO Escuela de Doctorado DS UVaDOC RD 19-nov-2024