RT info:eu-repo/semantics/article T1 Clinical characterisation of contact lens discomfort progression A1 Valencia-Nieto, Laura A1 López-de la Rosa, Alberto A1 López-Miguel, Alberto A1 González García, María J. K1 Lentes de contacto K1 Contact lens K1 Discomfort K1 Classification K1 Questionnaires K1 3201.09 Oftalmología AB Purpose: This study aimed to assess the subjective and objective differences among the steps of the contact lens discomfort (CLD) progression classification established by the Tear Film & Ocular Surface Society (TFOS) using questionnaires and clinical signs, and to propose a simplified classification.Methods: Contact lens (CL) wearers were evaluated in a single visit. The Contact Lens Dry Eye Questionnaire (CLDEQ)-8, the Contact Lens Discomfort Index, and Visual Analog Scales for discomfort and dryness were administered. The non-invasive break-up time, the tear film lipid layer thickness, conjunctival hyperaemia and papillae, lid-parallel conjunctival folds, the fluorescein tear film break-up time, corneal and conjunctival staining,lid wiper epitheliopathy, and the Schirmer test were assessed. Sign and symptom scores were compared among TFOS CLD progression steps using analysis of variance or the Kruskal–Wallis H test. Steps 1 and 2 (reduced comfort), and steps 3 and 4 (reduced wearing time) of the TFOS classification were combined to obtain a simplified classification, and the same comparison was performed. A p-value ≤ 0.05 was considered statistically significant.Results: One hundred-fifty CL wearers (97 women and 53 men) aged 34.4 ± 12.6 years were included. In the TFOS classification, there were significant differences between step 0 (no CLD) and the rest of the severity steps for the scores obtained in all questionnaires (p ≤ 0.015). All steps were differentiated (p ≤ 0.032) based on the simplified classification for all questionnaires, except steps 1 and 2 for the CLDEQ-8 and dryness VAS (p = 0.089 and p = 0.051, respectively). There were no differences (all p ≥ 0.06) between the sign scores among the steps of either classification.Conclusion: CLD management is encouraged from its first appearance. Simplifying the phases of CLD severity may allow a more accurate classification and a better awareness of the problem by clinicians and CL wearers by using more straightforward simple messages. PB Elsevier SN 1367-0484 YR 2024 FD 2024 LK https://uvadoc.uva.es/handle/10324/69558 UL https://uvadoc.uva.es/handle/10324/69558 LA eng NO Contact Lens and Anterior Eye, Febrero 2024, vol. 47, n. 1. NO Producción Científica DS UVaDOC RD 12-sep-2024