RT info:eu-repo/semantics/article
T1 Dyslipidemia and inflammation as hallmarks of oxidative stress in COVID-19: a follow-up study
A1 Aparisi Sanz, Álvaro
A1 Martín Fernández, Marta
A1 Ybarra Falcón, Cristina
A1 Gil, José Francisco
A1 Carrasco Moraleja, Manuel
A1 Martínez de Paz, Pedro José
A1 Cusácovich Torres, Iván
A1 Gonzalo Benito, Hugo
A1 Fuertes, Raúl
A1 Marcos Mangas, Marta
A1 Iglesias Echeverría, Carolina
A1 San Román Calvar, José Alberto
A1 Tamayo Gómez, Eduardo
A1 Andaluz Ojeda, David
A1 Tamayo Velasco, Álvaro
K1 Cholesterol
K1 Colesterol
K1 Lipoproteins
K1 Lipids
K1 Lipids - Peroxidation
K1 Lípidos
K1 Proteins
K1 Biochemistry
K1 Oxidative stress
K1 Estrés oxidativo
K1 COVID-19
K1 Inflammation
K1 Inflamación
K1 Medicine
K1 Molecular biology
K1 Dyslipidemia
K1 2302.27 Proteínas
K1 2302 Bioquímica
K1 32 Ciencias Médicas
K1 2415 Biología Molecular
AB Recent works have demonstrated a significant reduction in cholesterol levels and increased oxidative stress in patients with coronavirus disease 2019 (COVID-19). The cause of this alteration is not well known. This study aimed to comprehensively evaluate their possible association during the evolution of COVID-19. This is an observational prospective study. The primary endpoint was to analyze the association between lipid peroxidation, lipid, and inflammatory profiles in COVID-19 patients. A multivariate regression analysis was employed. The secondary endpoint included the long-term follow-up of lipid profiles. COVID-19 patients presented significantly lower values in their lipid profile (total, low, and high-density lipoprotein cholesterol) with greater oxidative stress and inflammatory response compared to the healthy controls. Lipid peroxidation was the unique oxidative parameter with a significant association with the total cholesterol (OR: 0.982; 95% CI: 0.969–0.996; p = 0.012), IL1-RA (OR: 0.999; 95% CI: 0.998–0.999; p = 0.021) IL-6 (OR: 1.062; 95% CI: 1.017–1.110; p = 0.007), IL-7 (OR: 0.653; 95% CI: 0.433–0.986; p = 0.042) and IL-17 (OR: 1.098; 95% CI: 1.010–1.193; p = 0.028). Lipid abnormalities recovered after the initial insult during long-term follow-up (IQR 514 days); however, those with high LPO levels at hospital admission had, during long-term follow-up, an atherogenic lipid profile. Our study suggests that oxidative stress in COVID-19 is associated with derangements of the lipid profile and inflammation. Survivors experienced a recovery in their lipid profiles during long-term follow-up, but those with stronger oxidative responses had an atherogenic lipid profile.
PB MDPI
SN 1422-0067
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/69654
UL https://uvadoc.uva.es/handle/10324/69654
LA eng
NO International Journal of Molecular Sciences, 2022, Vol. 23, Nº. 23, 15350
NO Producción Científica
DS UVaDOC
RD 22-dic-2024