RT info:eu-repo/semantics/article
T1 The thirty-fifth anniversary of K+ channels in O₂ sensing: what we know and what we don’t know
A1 Rocher Martín, María Asunción
A1 Aaronson, Philip Irving
K1 Oxigen
K1 Oxígeno
K1 Oxygen in the body
K1 Carotid body
K1 Cuerpo carotídeo
K1 Hypoxia
K1 Anoxemia
K1 Lungs - Blood-vessels - Diseases
K1 Pulmones - Vasos sanguíneos - Enfermedades
K1 Respiratory organs - Diseases
K1 Respiratorio, Aparato - Enfermedades
K1 Mitochondria
K1 Mitocondrias
K1 Reactive oxygen species
K1 Active oxygen
K1 Molecular biology
K1 Biochemistry
K1 Medicine
K1 2415 Biología Molecular
K1 2302 Bioquímica
K1 32 Ciencias Médicas
AB On the thirty-fifth anniversary of the first description of O₂-sensitive K+ channels in the carotid body chemoreceptors O₂ sensing remains a salient issue in the literature. Whereas much has been learned about this subject, important questions such as the identity of the specific K+ channel subtype(s) responsible for O₂ sensing by chemoreceptors and the mechanism(s) by which their activities are altered by hypoxia have not yet been definitively answered. O₂ sensing is a fundamental biological process necessary for the acute and chronic responses to varying environmental O₂ levels which allow organisms to adapt to hypoxia. Whereas chronic responses depend on the modulation of hypoxia-inducible transcription factors which determine the expression of numerous genes encoding enzymes, transporters and growth factors, acute responses rely mainly on the dynamic modulation of ion channels by hypoxia, causing adaptive changes in cell excitability, contractility and secretory activity in specialized tissues. The most widely studied oxygen-sensitive ion channels are potassium channels, but oxygen sensing by members of both the calcium and sodium channel families has also been demonstrated. Given the explosion of information on this topic, in this review, we will focus on the mechanisms of physiological oxygen chemotransduction by PO₂-dependent K+ channels, with particular emphasis on their function in carotid body chemoreceptor cells (CBCC) and pulmonary artery smooth muscle cells (PASMC), highlighting areas of consensus and controversy within the field. We will first describe the most well-established concepts, those reproduced in multiple laboratories, and then discuss selected observations or questions that remain unresolved, and that limit our progress in this field.
PB MDPI
SN 2673-9801
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/69691
UL https://uvadoc.uva.es/handle/10324/69691
LA eng
NO Oxygen, 2024, Vol. 4, Nº. 1, págs. 53-89
NO Producción Científica
DS UVaDOC
RD 18-nov-2024