RT info:eu-repo/semantics/article
T1 Calcium, phosphorus, and vitamin D levels in a series of cystic fibrosis patients: a cross-sectional study
A1 Escobedo Monge, Marlene Fabiola
A1 Marcos Temprano, Marianela
A1 Parodi Román, Joaquín
A1 Escobedo Monge, María Antonieta
A1 Alonso Vicente, Carmen
A1 Torres Hinojal, María Carmen
A1 Marugán de Miguelsanz, José Manuel
K1 Nutritional status
K1 Nutrición - Evaluación
K1 Calcium
K1 Calcio
K1 Phosphorus
K1 Fósforo
K1 Vitamina D
K1 Vitamina D
K1 Alkaline phosphatase
K1 Fosfatasa alcalina (Enzima)
K1 Physical activity
K1 Ejercicio físico
K1 Cystic fibrosis
K1 Fibrosis quística
K1 Lungs - Diseases
K1 Nutrition
K1 Medicine
K1 3206 Ciencias de la Nutrición
K1 3206.13 Vitaminas
K1 32 Ciencias Médicas
K1 3205.08 Enfermedades Pulmonares
AB Cystic fibrosis (CF) is a monogenic disease with different types of mutations that mainly affect the respiratory-digestive system. Calcium (Ca), phosphorus (P), and vitamin D (Vit-D) are essential nutrients for maintaining adequate growth and development, as well as key components in crucial metabolic pathways. Proper diagnosis, treatment, and response are decisive components of precision medicine. Therefore, we conducted a cross-sectional study to evaluate Ca, P, and Vit-D levels along with health and nutritional indicators, regarding their non-skeletal functions, in a series of CF patients. Anthropometric and clinical evaluation, biochemical analysis, dietary survey, and respiratory and pancreatic status were performed. Even though the results showed that all patients had normal dietary and serum Ca levels, 47% of patients had deficient Vit-D intake, 53% of patients had hypovitaminosis D, 35% had insufficient Vit-D levels, 18% had hypophosphatemia, 76% had elevated alkaline phosphate levels, 29% had hypercalciuria, and 65% had hyperphosphaturia. There were no significant differences between homozygous and compound heterozygous patients. Ca, P, and Vit-D levels were associated with body mass index; body composition; physical activity; diet; growth hormones; and the immune, liver, and kidney systems. We suggest a periodically evaluation of Ca and P losses.
PB MDPI
SN 1422-0067
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/69751
UL https://uvadoc.uva.es/handle/10324/69751
LA eng
NO International Journal of Molecular Sciences, 2024, Vol. 25, Nº. 3, 1900
NO Producción Científica
DS UVaDOC
RD 24-nov-2024