RT info:eu-repo/semantics/article T1 Is the combination of robot-assisted therapy and transcranial direct current stimulation useful for upper limb motor recovery? A systematic review with meta-analysis A1 Bernal Jiménez, Juan José A1 Polonio López, Begoña A1 Sanz García, Ancor A1 Martín Conty, José Luis A1 Lerín Calvo, Alfredo A1 Segura Fragoso, Antonio A1 Martín Rodríguez, Francisco A1 Cantero Garlito, Pablo A. A1 Corregidor Sánchez, Ana Isabel A1 Mordillo Mateos, Laura K1 Robotics K1 Robótica K1 Robotics in medicine K1 Robòtica en medicina K1 Transcranial direct current stimulation K1 Neurorehabilitation K1 Stroke K1 Cerebro - Enfermedades K1 Destreza manual K1 Spasticity K1 Espasticidad K1 Meta-analysis K1 Medicine K1 Neurology K1 Medical innovations K1 Public health K1 32 Ciencias Médicas K1 3205.07 Neurología K1 3314 Tecnología Médica K1 3212 Salud Publica AB Stroke is the third leading cause of disability in the world, and effective rehabilitation is needed to improve lost functionality post-stroke. In this regard, robot-assisted therapy (RAT) and transcranial direct current stimulation (tDCS) are promising rehabilitative approaches that have been shown to be effective in motor recovery. In the past decade, they have been combined to study whether their combination produces adjuvant and greater effects on stroke recovery. The aim of this study was to estimate the effectiveness of the combined use of RATs and tDCS in the motor recovery of the upper extremities after stroke. After reviewing 227 studies, we included nine randomised clinical trials (RCTs) in this study. We analysed the methodological quality of all nine RCTs in the meta-analysis. The analysed outcomes were deficit severity, hand dexterity, spasticity, and activity. The addition of tDCS to RAT produced a negligible additional benefit on the effects of upper limb function (SMD −0.09, 95% CI −0.31 to 0.12), hand dexterity (SMD 0.12, 95% CI −0.22 to 0.46), spasticity (SMD 0.04, 95% CI −0.24 to 0.32), and activity (SMD 0.66, 95% CI −1.82 to 3.14). There is no evidence of an additional effect when adding tDCS to RAT for upper limb recovery after stroke. Combining tDCS with RAT does not improve upper limb motor function, spasticity, and/or hand dexterity. Future research should focus on the use of RAT protocols in which the patient is given an active role, focusing on the intensity and dosage, and determining how certain variables influence the success of RAT. PB MDPI SN 2227-9032 YR 2024 FD 2024 LK https://uvadoc.uva.es/handle/10324/69806 UL https://uvadoc.uva.es/handle/10324/69806 LA eng NO Healthcare, 2024, Vol. 12, Nº. 3, 337 NO Producción Científica DS UVaDOC RD 09-ene-2025