RT info:eu-repo/semantics/article
T1 Validation of quantitative flow ratio-derived virtual angioplasty with post-angioplasty fractional flow reserve—the QIMERA-I study
A1 Amat Santos, Ignacio Jesús
A1 Marengo, Giorgio
A1 Sánchez Luna, Juan Pablo
A1 Cortés Villar, Carlos
A1 Rivero Crespo, Fernando
A1 Jiménez Díaz, Víctor Alfonso
A1 Torre Hernández, José María de la
A1 Pérez de Prado, Armando
A1 Sabaté, Manel
A1 López Palop, Ramón
A1 Vegas Valle, José Miguel
A1 Suárez de Lezo, Javier
A1 Fernández Cordón, Clara
A1 González Gutiérrez, José Carlos
A1 García Gómez, Mario
A1 Redondo Diéguez, Alfredo
A1 Carrasco Moraleja, Manuel
A1 San Román Calvar, José Alberto
K1 Cardiovascular system - Diseases
K1 Sistema cardiovascular - Enfermedades
K1 Cardiovascular Physiology
K1 Blood - Circulation
K1 Sangre - Circulación
K1 Angioplasty
K1 Angioplastia
K1 Medicine
K1 Cardiology
K1 32 Ciencias Médicas
K1 3205.01 Cardiología
K1 2411.03 Fisiología Cardiovascular
AB Background: Quantitative flow ratio (QFR) virtual angioplasty with pre-PCI residual QFR showed better results compared with an angiographic approach to assess post-PCI functional results. However, correlation with pre-PCI residual QFR and post-PCI fractional flow reserve (FFR) is lacking. Methods: A multicenter prospective study including consecutive patients with angiographically 50–90% coronary lesions and positive QFR results. All patients were evaluated with QFR, hyperemic and non-hyperemic pressure ratios (NHPR) before and after the index PCI. Pre-PCI residual QFR (virtual angioplasty) was calculated and compared with post-PCI fractional flow reserve (FFR), QFR and NHPR. Results: A total of 84 patients with 92 treated coronary lesions were included, with a mean age of 65.5 ± 10.9 years and 59% of single vessel lesions being the left anterior descending artery in 69%. The mean vessel diameter was 2.82 ± 0.41 mm. Procedural success was achieved in all cases, with a mean number of implanted stents of 1.17 ± 0.46. The baseline QFR value was 0.69 ± 0.12 and baseline FFR and NHPR were 0.73 ± 0.08 and 0.82 ± 0.11, respectively. Mean post-PCI FFR increased to 0.87 ± 0.05 whereas residual QFR had been estimated as 0.95 ± 0.05, showing poor correlation with post-PCI FFR (0.163; 95% CI:0.078–0.386) and low diagnostic accuracy (30.9%, 95% CI:20–43%). Conclusions: In this analysis, the results of QFR-based virtual angioplasty did not seem to accurately correlate with post-PCI FFR.
PB MDPI
SN 2308-3425
YR 2023
FD 2023
LK https://uvadoc.uva.es/handle/10324/70061
UL https://uvadoc.uva.es/handle/10324/70061
LA eng
NO Journal of Cardiovascular Development and Disease, 2024, Vol. 11, Nº. 1, 14
NO Producción Científica
DS UVaDOC
RD 24-nov-2024