RT info:eu-repo/semantics/article
T1 Electrophilic compounds in the human diet and their role in the induction of the transcription factor NRF2
A1 Curieses Andrés, Celia María
A1 Pérez de la Lastra, José Manuel
A1 Bustamante Munguira, Elena
A1 Andrés Juan, Celia
A1 Plou, Francisco J.
A1 Pérez Lebeña, Eduardo
K1 Electrophilic compounds
K1 Organic chemistry
K1 Polyphenols
K1 Polifenoles
K1 Hydrogen sulfide
K1 Oxidative stress
K1 Estrés oxidativo
K1 Chemical reactions
K1 Reacciones químicas
K1 Nutrition
K1 Alimentación
K1 Dieta
K1 Dieta
K1 Medicine
K1 Public health
K1 2306 Química Orgánica
K1 3206 Ciencias de la Nutrición
K1 32 Ciencias Médicas
K1 3212 Salud Publica
AB The phrase “Let food be thy medicine…” means that food can be a form of medicine and medicine can be a form of food; in other words, that the diet we eat can have a significant impact on our health and well-being. Today, this phrase is gaining prominence as more and more scientific evidence suggests that one’s diet can help prevent and treat disease. A diet rich in fruits, vegetables, whole grains, and lean protein can help reduce the risk of heart disease, cancer, diabetes, and other health problems and, on the other hand, a diet rich in processed foods, added sugars, and saturated fats can increase the risk of the same diseases. Electrophilic compounds in the diet can have a significant impact on our health, and they are molecules that covalently modify cysteine residues present in the thiol-rich Keap1 protein. These compounds bind to Keap1 and activate NRF2, which promotes its translocation to the nucleus and its binding to DNA in the ARE region, triggering the antioxidant response and protecting against oxidative stress. These compounds include polyphenols and flavonoids that are nucleophilic but are converted to electrophilic quinones by metabolic enzymes such as polyphenol oxidases (PPOs) and sulfur compounds present in foods such as the Brassica genus (broccoli, cauliflower, cabbage, Brussel sprouts, etc.) and garlic. This review summarizes our current knowledge on this subject.
PB MDPI
SN 1422-0067
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/70131
UL https://uvadoc.uva.es/handle/10324/70131
LA eng
NO International Journal of Molecular Sciences, 2024, Vol. 25, Nº. 6, 3521
NO Producción Científica
DS UVaDOC
RD 24-nov-2024