RT info:eu-repo/semantics/article
T1 Pumping up the fight against multiple sclerosis: the effects of high-intensity resistance training on functional capacity, muscle mass, and axonal damage
A1 Maroto Izquierdo, Sergio
A1 Mulero Carrillo, Patricia
A1 Menéndez, Héctor
A1 Pinto Fraga, Francisco José
A1 Lista, Simone
A1 Santos Lozano, Alejandro
A1 Téllez Lara, María de las Nieves
K1 Neurosciences
K1 Neurodegeneration
K1 Nervous system - Diseases
K1 Nervioso, Sistema - Enfermedades
K1 Exercise
K1 Ejercicio físico
K1 Sports - Physiological aspects
K1 Deportes - Aspectos fisiológicos
K1 Sport Training
K1 Entrenamiento (Deportes)
K1 Muscle hypertrophy
K1 Cuerpo humano - Hipertrofia
K1 Physical function
K1 Multiple sclerosis
K1 Esclerosis lateral amiotrófica
K1 Medicine
K1 Neurology
K1 Public health
K1 2490 Neurociencias
K1 32 Ciencias Médicas
K1 3205.07 Neurología
K1 2411.06 Fisiología del Ejercicio
K1 3212 Salud Publica
AB Background: Resistance training (RT) has been recognized as a beneficial non-pharmacological intervention for multiple sclerosis (MS) patients, but its impact on neurodegeneration is not fully understood. This study aimed to investigate the effects of high-intensity RT on muscle mass, strength, functional capacity, and axonal damage in MS patients. Methods: Eleven relapsing–remitting MS patients volunteered in this within-subject counterbalanced intervention study. Serum neurofilament light-chain (NfL) concentration, vastus lateralis thickness (VL), timed up-and-go test (TUG), sit-to-stand test (60STS), and maximal voluntary isometric contraction (MVIC) were measured before and after intervention. Participants performed 18 sessions of high-intensity RT (70–80% 1-RM) over 6 weeks. Results: Significant (p < 0.05) differences were observed post-intervention for VL (ES = 2.15), TUG (ES = 1.98), 60STS (ES = 1.70), MVIC (ES = 1.78), and NfL (ES = 1.43). Although moderate correlations between changes in VL (R = 0.434), TUG (R = −0.536), and MVIC (R = 0.477) and changes in NfL were observed, only the correlation between VL and MVIC changes was significant (R = 0.684, p = 0.029). Conclusions: A 6-week RT program significantly increased muscle mass, functional capacity, and neuromuscular function while also decreasing serum NfL in MS patients. These results suggest the effectiveness of RT as a non-pharmacological approach to mitigate neurodegeneration while improving functional capacity in MS patients.
PB MDPI
SN 2227-9032
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/70243
UL https://uvadoc.uva.es/handle/10324/70243
LA eng
NO Healthcare, 2024, Vol. 12, Nº. 8, 837
NO Producción Científica
DS UVaDOC
RD 08-ene-2025