RT info:eu-repo/semantics/article T1 Genetic modifications in bacteria for the degradation of synthetic polymers: a review A1 Martín González, Diego A1 Fuente Tagarro, Carlos de la A1 Lucas, Andrea de A1 Bordel Velasco, Sergio A1 Santos Beneit, Fernando K1 Polymers K1 Polimeros y polimerización K1 Plastics K1 Materias plásticas K1 Biodegradation K1 Biodegradación K1 Genetic engineering K1 Tomography K1 Tomografía K1 Microbial biotechnology K1 Biotecnologia microbiana K1 Biotechnology K1 Microbiology K1 Environmental engineering K1 2206.10 Polímeros K1 2409.02 Ingeniería Genética K1 2414 Microbiología K1 3312 Tecnología de Materiales K1 3308 Ingeniería y Tecnología del Medio Ambiente AB Synthetic polymers, commonly known as plastics, are currently present in all aspects of our lives. Although they are useful, they present the problem of what to do with them after their lifespan. There are currently mechanical and chemical methods to treat plastics, but these are methods that, among other disadvantages, can be expensive in terms of energy or produce polluting gases. A more environmentally friendly alternative is recycling, although this practice is not widespread. Based on the practice of the so-called circular economy, many studies are focused on the biodegradation of these polymers by enzymes. Using enzymes is a harmless method that can also generate substances with high added value. Novel and enhanced plastic-degrading enzymes have been obtained by modifying the amino acid sequence of existing ones, especially on their active site, using a wide variety of genetic approaches. Currently, many studies focus on the common aim of achieving strains with greater hydrolytic activity toward a different range of plastic polymers. Although in most cases the depolymerization rate is improved, more research is required to develop effective biodegradation strategies for plastic recycling or upcycling. This review focuses on a compilation and discussion of the most important research outcomes carried out on microbial biotechnology to degrade and recycle plastics. PB MDPI SN 1422-0067 YR 2024 FD 2024 LK https://uvadoc.uva.es/handle/10324/70374 UL https://uvadoc.uva.es/handle/10324/70374 LA eng NO International Journal of Molecular Sciences, 2024, Vol. 25, Nº. 10, 5536 NO Producción Científica DS UVaDOC RD 14-oct-2024