RT info:eu-repo/semantics/article
T1 Gray Matter Structural Alterations in Chronic and Episodic Migraine: A Morphometric Magnetic Resonance Imaging Study
A1 Planchuelo Gómez, Álvaro
A1 García Azorín, David
A1 Guerrero Peral, Angel Luis
A1 Rodríguez Velasco, Margarita
A1 Aja Fernández, Santiago
A1 Luis García, Rodrigo de
K1 Chronic Migraine
K1 Migraine
K1 Magnetic Resonance Imaging
K1 Cortical Curvature
K1 Cortical Thickness
K1 Gray Matter Volume
K1 Surface Area
AB Objective. This study evaluates different parameters describing the gray matter structure to analyze differences between healthy controls, patients with episodic migraine, and patients with chronic migraine. Design. Cohort study. Setting. Spanish community. Subjects. Fifty-two healthy controls, 57 episodic migraine patients, and 57 chronic migraine patients were included in the study and underwent T1-weighted magnetic resonance imaging acquisition. Methods. Eighty-four cortical and subcortical gray matter regions were extracted, and gray matter volume, cortical curvature, thickness, and surface area values were computed (where applicable). Correlation analysis between clinical features and structural parameters was performed. Results. Statistically significant differences were found between all three groups, generally consisting of increases in cortical curvature and decreases in gray matter volume,cortical thickness, and surface area in migraineurs with respect to healthy controls. Furthermore, differences were also found between chronic and episodic migraine. Significant correlations were found between duration of migraine history and several structural parameters. Conclusions. Migraine is associated with structural alterations in widespread gray matter regions of the brain. Moreover, the results suggest that the pattern of differences between healthy controls and episodic migraine patients is qualitatively different from that occurring between episodic and chronic migraine patients.
PB Oxford University Press
SN 1526-2375
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/70535
UL https://uvadoc.uva.es/handle/10324/70535
LA eng
NO Pain Medicine, vol. 21, n. 11, p. 2997-3011
DS UVaDOC
RD 05-abr-2025