RT info:eu-repo/semantics/article
T1 Structural connectivity alterations in chronic and episodic migraine: A diffusion magnetic resonance imaging connectomics study
A1 Planchuelo Gómez, Álvaro
A1 García Azorín, David
A1 Guerrero Peral, Angel Luis
A1 Aja Fernández, Santiago
A1 Rodríguez Velasco, Margarita
A1 Luis García, Rodrigo de
K1 Migraine
K1 Chronic Migraine
K1 Diffusion-weighted imaging
K1 Tractography
K1 Magnetic resonance imaging (MRI)
K1 Connectomics
AB Objective: To identify possible structural connectivity alterations in patients with episodic and chronic migraine using magnetic resonance imaging data.Methods: Fifty-four episodic migraine, 56 chronic migraine patients and 50 controls underwent T1-weighted and diffusion-weighted magnetic resonance imaging acquisitions. Number of streamlines (trajectories of estimated fiber-tracts), mean fractional anisotropy, axial diffusivity and radial diffusivity were the connectome measures. Correlation analysis between connectome measures and duration and frequency of migraine was performed.Results: Higher and lower number of streamlines were found in connections involving regions like the superior frontal gyrus when comparing episodic and chronic migraineurs with controls (p<.05 false discovery rate). Between the left caudal anterior cingulate and right superior frontal gyri, more streamlines were found in chronic compared to episodic migraine. Higher and lower fractional anisotropy, axial diffusivity, and radial diffusivity were found between migraine groups and controls in connections involving regions like the hippocampus. Lower radial diffusivity and axial diffusivity were found in chronic compared to episodic migraine in connections involving regions like the putamen. In chronic migraine, duration of migraine was positively correlated with fractional anisotropy and axial diffusivity.Conclusions: Structural strengthening of connections involving subcortical regions associated with pain processing and weakening in connections involving cortical regions associated with hyperexcitability may coexist in migraine.
PB SAGE Publications
SN 0333-1024
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/70540
UL https://uvadoc.uva.es/handle/10324/70540
LA eng
NO Cephalalgia, 2020, vol. 40, n. 4, p. 367-383
DS UVaDOC
RD 15-oct-2024