RT info:eu-repo/semantics/article
T1 Deep Phenotyping of Headache in Hospitalized COVID-19 Patients via Principal Component Analysis
A1 Planchuelo Gómez, Álvaro
A1 Trigo López, Javier
A1 Luis García, Rodrigo de
A1 Guerrero Peral, Angel Luis
A1 Porta Etessam, Jesús
A1 García Azorín, David
K1 COVID-19
K1 Headache disorders
K1 Migraine
K1 Tension-type headache
K1 Machine learning
AB Objectives: Headache is a common symptom in systemic infections, and one of the symptoms of the novel coronavirus disease 2019 (COVID-19). The objective of this study was to characterize the phenotype of COVID-19 headache via machine learning.Methods: We performed a cross-sectional study nested in a retrospective cohort. Hospitalized patients with COVID-19 confirmed diagnosis who described headache were included in the study. Generalized Linear Models and Principal Component Analysis were employed to detect associations between intensity and self-reported disability caused by headache, quality and topography of headache, migraine features, COVID-19 symptoms, and results from laboratory tests.Results: One hundred and six patients were included in the study, with a mean age of 56.6 ± 11.2, including 68 (64.2%) females. Higher intensity and/or disability caused by headache were associated with female sex, fever, abnormal platelet count and leukocytosis, as well as migraine symptoms such as aggravation by physical activity, pulsating pain, and simultaneous photophobia and phonophobia. Pain in the frontal area (83.0% of the sample), pulsating quality, higher intensity of pain, and presence of nausea were related to lymphopenia. Pressing pain and lack of aggravation by routine physical activity were linked to low C-reactive protein and procalcitonin levels.Conclusion: Intensity and disability caused by headache attributed to COVID-19 are associated with the disease state and symptoms. Two distinct headache phenotypes were observed in relation with COVID-19 status. One phenotype seems to associate migraine symptoms with hematologic and inflammatory biomarkers of severe COVID-19; while another phenotype would link tension-type headache symptoms to milder COVID-19.
PB Frontiers
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/70546
UL https://uvadoc.uva.es/handle/10324/70546
LA eng
NO Frontiers in Neurology, 2020, vol. 11, p. 583870
NO Producción Científica
DS UVaDOC
RD 19-nov-2024