RT info:eu-repo/semantics/article
T1 Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study
A1 Trigo López, Javier
A1 García Azorín, David
A1 Planchuelo Gómez, Álvaro
A1 Martínez Pías, Enrique
A1 Talavera, Blanca
A1 Hernández Pérez, Isabel
A1 Valle Peñacoba, Gonzalo
A1 Simón Campo, Paula
A1 de Lera, Mercedes
A1 Chavarría Miranda, Alba
A1 López Sanz, Cristina
A1 Gutiérrez Sánchez, María
A1 Martínez Velasco, Elena
A1 Pedraza, María I.
A1 Sierra Mencía, Álvaro
A1 Gómez Vicente, Beatriz
A1 Arenillas Lara, Juan Francisco
A1 Guerrero Peral, Angel Luis
K1 COVID-19
K1 Headache disorders
K1 Secondary
K1 Mortality
K1 Laboratory parameters
K1 Nervous system diseases
AB Introduction: Headache is one of the most frequent neurologic manifestations in COVID-19. We aimed to analyze which symptoms and laboratory abnormalities were associated with the presence of headache and to evaluate if patients with headache had a higher adjusted in-hospital risk of mortality.Methods: Retrospective cohort study. We included all consecutive patients admitted to the Hospital with confirmed SARS-CoV-2 infection between March 8th and April 11th, 2020. We collected demographic data, clinical variables and laboratory abnormalities. We used multivariate regression analysis.Results: During the study period, 576 patients were included, aged 67.2 (SD: 14.7), and 250/576 (43.3%) being female. Presence of headache was described by 137 (23.7%) patients. The all-cause in-hospital mortality rate was 127/576 (20.0%). In the multivariate analysis, patients with headache had a lower risk of mortality (OR: 0.39, 95% CI: 0.17-0.88, p = 0.007). After adjusting for multiple comparisons in a multivariate analysis, variables that were independently associated with a higher odds of having headache in COVID-19 patients were anosmia, myalgia, female sex and fever; variables that were associated with a lower odds of having headache were younger age, lower score on modified Rankin scale, and, regarding laboratory variables on admission, increased C-reactive protein, abnormal platelet values, lymphopenia and increased D-dimer.Conclusion: Headache is a frequent symptom in COVID-19 patients and its presence is an independent predictor of lower risk of mortality in COVID-19 hospitalized patients.
PB Springer Nature
SN 1129-2369
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/70609
UL https://uvadoc.uva.es/handle/10324/70609
LA eng
NO The Journal of Headache and Pain, vol. 21, n. 1, p. 94
DS UVaDOC
RD 19-nov-2024