RT info:eu-repo/semantics/article
T1 Perceived quality of life (QOLIE-31-P), depression (NDDI-E), anxiety (GAD-7), and insomnia in patients with epilepsy attended at a refractory epilepsy unit in real-life clinical practice
A1 González Martínez, Alicia
A1 Planchuelo Gómez, Álvaro
A1 Vieira Campos, Alba
A1 Martínez Dubarbie, Francisco
A1 Vivancos, José
A1 De Toledo Heras, María
K1 Anxiety
K1 Depression
K1 Drug-resistant epilepsy
K1 QOLIE-31-P
K1 Quality of life
K1 Sleep disturbances
AB Objectives: This study aims to evaluate the relationship between psychiatric comorbidity (anxiety and depression), somnolence, and quality of life, using validated scales in patients with epilepsy in real-life clinical practice and clinical and demographic variables.Methods: A cross-sectional observational study was conducted. Self-administered scales of anxiety disorders (GAD-7), depression (NDDI-E), somnolence (Epworth Sleepiness Scale (ESS)), and quality of life (QOLIE-31-P) in patients with epilepsy treated in the refractory epilepsy unit of a tertiary hospital were employed.Results: Eighty-four patients, 44.3 ± 17.4 years, 48.2% women, epilepsy duration 21.5 ± 15.9 years, and number of antiepileptic drugs 1.9 ± 1.2 were included. Severe anxiety was present in 14.3%, depression in 20.2%, and somnolence in 14.3% of patients. QOLIE-31-P score was 62.0 ± 19.2. Depression and focal epilepsy (OR = 4.5[1.3, 20.7], p = 0.029), as well as anxiety and temporal lobe epilepsy (OR = 4.3 [1.0, 18.1], p = 0.044), were associated. Moreover, relationships between worse quality of life and higher scores from NDDI-E (β = - 1.42, adjusted p = 0.006) and GAD-7 (β = - 1.21, adjusted p = 0.006), especially in drug-resistant epilepsy (β = - 8.08, adjusted p = 0.045) and female sex (β = - 7.83, adjusted p = 0.034), were identified. Statistically significant negative associations were observed between problems to fall asleep and overall quality of life score (β = - 11.64, adjusted p = 0.022), sleep disturbance and energy (β = - 14.78, adjusted p = 0.027), and mood (β = 12.40, adjusted p = 0.027) scores.Conclusions: The multidimensional evaluation revealed that higher levels of anxiety and depression are associated with worse quality of life in real clinical practice in patients with epilepsy, especially in females and drug-resistant epilepsy. In addition, sleep disturbances are associated with particular aspects of the quality of life. Further studies with longitudinal follow-up would be useful to adequately manage these comorbidities in patients with epilepsy.
PB Springer Nature
SN 1590-1874
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/70610
UL https://uvadoc.uva.es/handle/10324/70610
LA eng
NO Neurological Sciences, vol. 43, n.3, p. 1955-1964
DS UVaDOC
RD 19-oct-2024