RT info:eu-repo/semantics/article
T1 Genetic variants in obesity-related genes and the risk of osteoporotic fracture. The Hortega Follow-up Study
A1 Martín-Escudero, Juan Carlos
A1 Chaves, Felipe J.
A1 García-García, Ana B.
A1 Martín-Vallejo, Javier
A1 García-Sorribes, Soraya
A1 Lara-Hernandez, Francisco
A1 Abadía-Otero, Jesica
A1 Briongos-Figuero, Laisa
A1 Pérez-Castrillón, Jose Luis
A1 Usategui-Martín, Ricardo
K1 Bone fracture; FTO and NEGR1; Obesity; Osteoporosis; Polymorphism.
AB Background: Osteoporosis and obesity are major public health problems that are closely correlated, as they share various features, including a genetic predisposition. A genetic correlation between obesity and osteoporosis due to the biological common pathways of bone and fat metabolism, which implies pleiotropic genes regulating has been described. The objective of our study was to analyse whether polymorphisms in obesity-related genes modify the risk of osteoporotic bone fracture.Methods: We studied 575 subjects from the Hortega Study. The subjects were followed-up for 12-14 years. 202 subjects were overweight, 143 obese and 221 had bone fractures. The distribution of 39 genetic variants in 22 obesity-related genes were studied.Results: The results showed a relationship between polymorphisms in the FTO and NEGR1 genes and the susceptibility to osteoporotic fracture. The variant genotype of the rs2568958 NEGR1 polymorphism and the rs6499649, rs3751812, and rs8044769 genetic variants in FTO were associated with susceptibility to bone fracture. In the best of our knowledge, this is the first time that these variants in NEGR1 and FTO genes have been associated with the susceptibility to osteoporotic bone fracture, supporting the hypothesis that the NEGR1 and FTO genes might be candidates for osteoporosis and bone fracture.Conclusions: In conclusion, this study associates obesity-related polymorphisms in the NEGR1 and FTO genes with osteoporotic bone fracture, reinforcing the hypothesis that obesity and bone metabolism are closely correlated genetically.
PB IMR Press
SN 2768-6701
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/70985
UL https://uvadoc.uva.es/handle/10324/70985
LA eng
NO Front Biosci (Landmark Ed). 2022 Jan 18;27(1):32
DS UVaDOC
RD 12-nov-2024