RT info:eu-repo/semantics/article
T1 Chemoreception in the context of the general biology of ROS
A1 González, Constancio
A1 Agapito Serrano, María Teresa
A1 Rocher Martín, María Asunción
A1 Martín González, María del Carmen
A1 Vega Agapito, María Victoria
A1 Gómez Niño, María Ángeles
A1 Rigual Bonastre, Ricardo Jaime
A1 Castañeda, Javier
A1 Obeso Cáceres, Ana María de la Luz
K1 Respiración celular
AB Superoxide anion is the most important reactive oxygen species (ROS) primarily generated in cells. The main cellular constituents with capabilitiesto generate superoxide anion areNADPHoxidases and mitochondrial respiratory chain. The emphasis of our article is centered in critically examininghypotheses proposing that ROS generated by NADPH oxidase and mitochondria are key elements in O2-sensing and hypoxic responses generationin carotid body chemoreceptor cells. Available data indicate that chemoreceptor cells express a specific isoform of NADPH oxidase that is activatedby hypoxia; generated ROS acting as negative modulators of the carotid body (CB) hypoxic responses. Literature is also consistent in supportingthat poisoned respiratory chain can produce high amounts of ROS, making mitochondrial ROS potential triggers-modulators of the CB activationelicited by mitochondrial venoms. However, most data favour the notion that levels of hypoxia, capable of strongly activating chemoreceptor cells,would not increase the rate of ROS production in mitochondria, making mitochondrial ROS unlikely triggers of hypoxic responses in the CB.Finally, we review recent literature on heme oxygenases from two perspectives, as potential O2-sensors in chemoreceptor cells and as generatorsof bilirubin which is considered to be a ROS scavenger of major quantitative importance in mammalian cells.
PB Elsevier
SN 1569-9048
YR 2007
FD 2007
LK http://uvadoc.uva.es/handle/10324/7121
UL http://uvadoc.uva.es/handle/10324/7121
LA eng
NO Respiratory Physiology & Neurobiology 157 (2007) 30–44
NO Producción Científica
DS UVaDOC
RD 24-nov-2024