RT info:eu-repo/semantics/article
T1 Meta-analysis of the rs243865 MMP-2 polymorphism and age-related macular degeneration risk
A1 Usategui Martín, Ricardo
A1 Pastor Idoate, Salvador
A1 Chamorro, Antonio J.
A1 Fernández Martínez, Itziar
A1 Fernández Bueno, Iván
A1 Marcos Martín, Miguel
A1 González Sarmiento, Rogelio
A1 Pastor Jimeno, José Carlos
AB Purpose: Several researchers have suggested that the rs243865 (16q13-q21) polymorphism in the promoter region of the metalloproteinase-2 (MMP-2) gene could be associated with an increased risk of developing age-related macular degeneration (AMD). However, previous results remain inconclusive. To clarify this controversy, we conducted a meta-analysis of the relationship between rs243865 of MMP-2 and AMD.Methods: We included 6 independent case-control studies involving 1,682 AMD patients and 2,295 healthy subjects. The association between the rs243865 polymorphism and AMD was examined by the overall odds ratio (OR) with a 95% confidence interval (CI). We used a recessive genetic model analysis, sensitivity analysis, and assessment of bias in our meta-analysis.Results: Our results showed that there was no significant association between the variant T allele (p-value = 0.10, OR [95%CI] = 0.95 [0.82–1.10]) or the CT+TT genotype (p-value = 0.16, OR [95%CI] = 0.92 [0.76–1.12]) of rs243865 MMP-2 polymorphism and the presence of AMD.Conclusions: The rs243865 MMP-2 polymorphism was not associated with an increased risk of developing AMD. The MMP-2 (-1306 C>T) promoter variant is unlikely to have a major role in AMD risk susceptibility.
YR 2019
FD 2019
LK https://uvadoc.uva.es/handle/10324/71448
UL https://uvadoc.uva.es/handle/10324/71448
LA eng
NO PLoS One, 2019, vol.14, n. 3, e0213624
NO Producción Científica
DS UVaDOC
RD 23-ene-2025