RT info:eu-repo/semantics/doctoralThesis
T1 Influencia de biomarcadores en la calidad de vida, estado de salud y fuerza muscular en población mayor de 65 años
A1 Giaquinta Aranda, Andrea
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Envejecimiento
K1 Aging
K1 Envejecimiento
K1 Quality of Life
K1 Calidad de Vida
K1 Vitamin D
K1 Health Status
K1 Estado de salud
K1 32 Ciencias Médicas
AB The progressive aging of the population is combined with the increase in the prevalence and incidence of multiple pathologies and comorbidities, which means a worse quality of life. Currently, there is an urgent need to advance health care and education with the aim of achieving a more active and autonomous society. Chronic pathologies in Spain generate around 70% of health expenditure, with the most demanding being the care of those over 65 years of age. Thanks to the Clinical Risk Groups (CRG), the health system of Castilla y León (SaCyL) classifies patients based on morbidity and chronicity in order to plan care and optimize resources in four groups (G0, G1, G2 and G3). However, this classification does not take into account the patient's perspective regarding their self-perception of quality of life, which could be of great consideration for a correct initial assignment.On the other hand, the identification of biomarkers related to the worsening of quality of life, as well as processes related to it such as physical activity, could involve the use of new modifiable targets for new interventions in gerontology. It is a priority to improve the quality of life in aging to have a good functional state and thus be able to prevent geriatric syndromes, one of them being sarcopenia, characterized by the loss of strength and functionality. There are specific genes related to muscle strength such as the ACTN3 gene that produce benefits on muscle fibers depending on the availability of the variant in older people.In turn, greater knowledge of vitamin D and other biomarkers could be interesting in this population group. Today we know that vitamin D behaves like a hormone with multiple functions in the body, the best studied being that related to bone health. Various genes are involved in the metabolism of this vitamin, producing negative effects on the risk of suffering from diseases such as osteoporosis, another of the most prevalent geriatric syndromes.
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/71456
UL https://uvadoc.uva.es/handle/10324/71456
LA spa
NO Escuela de Doctorado
DS UVaDOC
RD 04-dic-2024