RT info:eu-repo/semantics/article
T1 Revealing the structure of 6-aminopenillanic acid: The active nucleus of penicillins
A1 Mato Domínguez, Sergio
A1 Mata López, Santiago
A1 Alonso Alonso, Elena Rita
A1 León Ona, Iker
K1 Antimicrobial agents
K1 Carbonyls
K1 Molecular structure
K1 Molecules
K1 Peptides and proteins
K1 23 Química
AB 6-Aminopenicillanic acid is a penicillanic acid compound and is the active nucleus common to all penicillins. Using laser ablation techniques, we transformed the solid into the gas phase and characterized its conformational panorama by combining supersonic expansions and Fourier transform microwave techniques. Five conformers were determined, adopting different spatial configurations. Among them, the axial and equatorial forms, which are biologically relevant, have been observed. The structural similarity to d-Ala-d-Ala and the detection of both axial and equatorial forms could explain its potential as a penicillin core and its capability as an antibiotic.
PB ACS (American Chemical Society)
SN 1948-7185
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/72618
UL https://uvadoc.uva.es/handle/10324/72618
LA eng
NO The Journal of Physical Chemistry Letters, 2024, vol. 15, n. 7, p. 1908-1913
NO Producción Científica
DS UVaDOC
RD 29-ene-2025