RT info:eu-repo/semantics/article
T1 Topical Quercetin and Resveratrol Protect the Ocular Surface in Experimental Dry Eye Disease
A1 Abengózar-Vela, Antonio
A1 Schaumburg, Chris S.
A1 Stern, Michael E.
A1 Calonge, Margarita
A1 Enríquez-de-Salamanca, Amalia
A1 González-García, María Jesús
K1 Desiccating stress, dry eye syndrome, inflammation, quercetin, resveratrol
AB Purpose: To determine the anti-inflammatory effect of quercetin (QCT),resveratrol (RES), and their combination in a dry eye disease (DED) model.Methods: DED was induced by exposing mice to a desiccating stress (DS);0.01%QCT, 0.1%RES, 0.01%QCT+0.1%RES (QCT+RES) or vehicle weretopically applied. Additionally, CD4+ T cells isolated from DS-exposed micewere transferred to athymic recipient mice. Corneal fluorescein staining, tearproduction and tear cytokine levels were evaluated in DS-exposed mice, andconjunctival CD4+ T cell infiltration was evaluated in recipient mice.Results: Corneal staining increased in DS-exposed mice, being reduced byQCT (p<0.001) and QCT+RES (p<0.05). DS induced an increase of IL-1αconcentration that was reduced by QCT, RES and QCT+RES (p<0.05, 0.01 and0.01, respectively). CD4+ T cells increased in recipients of DS-exposed mice(p<0.05), and was lower in recipients of QCT- and RES-treated mice (p<0.05).Conclusion: The anti-inflammatory effect of polyphenols suggests their topicalapplication for DED.
PB Taylor & Francis
SN 0927-3948
YR 2019
FD 2019
LK https://uvadoc.uva.es/handle/10324/72725
UL https://uvadoc.uva.es/handle/10324/72725
LA eng
NO Ocular Immunology and Inflammation, 2019;27:1023-1032
NO Producción Científica
DS UVaDOC
RD 26-dic-2024