RT info:eu-repo/semantics/article
T1 Topical Quercetin and Resveratrol Protect the Ocular Surface in Experimental Dry Eye Disease
A1 Abengózar Vela, Antonio
A1 Schaumburg, Chris S.
A1 Stern, Michael E.
A1 Calonge, Margarita
A1 Enriquez De Salamanca Aladro, Amalia
A1 González García, María Jesús
K1 Desiccating stress, dry eye syndrome, inflammation, quercetin, resveratrol
AB Purpose: To determine the anti-inflammatory effect of quercetin (QCT),resveratrol (RES), and their combination in a dry eye disease (DED) model.Methods: DED was induced by exposing mice to a desiccating stress (DS);0.01%QCT, 0.1%RES, 0.01%QCT+0.1%RES (QCT+RES) or vehicle weretopically applied. Additionally, CD4+ T cells isolated from DS-exposed micewere transferred to athymic recipient mice. Corneal fluorescein staining, tearproduction and tear cytokine levels were evaluated in DS-exposed mice, andconjunctival CD4+ T cell infiltration was evaluated in recipient mice.Results: Corneal staining increased in DS-exposed mice, being reduced byQCT (p<0.001) and QCT+RES (p<0.05). DS induced an increase of IL-1αconcentration that was reduced by QCT, RES and QCT+RES (p<0.05, 0.01 and0.01, respectively). CD4+ T cells increased in recipients of DS-exposed mice(p<0.05), and was lower in recipients of QCT- and RES-treated mice (p<0.05).Conclusion: The anti-inflammatory effect of polyphenols suggests their topicalapplication for DED.
PB Taylor & Francis
SN 0927-3948
YR 2019
FD 2019
LK https://uvadoc.uva.es/handle/10324/72725
UL https://uvadoc.uva.es/handle/10324/72725
LA eng
NO Ocular Immunology and Inflammation, 2019;27:1023-1032
NO Producción Científica
DS UVaDOC
RD 25-abr-2025