RT info:eu-repo/semantics/article
T1 Inflammatory status predicts contact lens discomfort under adverse environmental conditions
A1 Fernández, Itziar
A1 López Miguel, Alberto
A1 Martín-Montañez, Vicente
A1 Enríquez-de-Salamanca, Amalia
A1 Calonge, Margarita
A1 González-Méijome, José M.
A1 González-García, María J.
K1 Contact lens discomfort, contact lens symptoms, controlled adverse desiccating environment, tear cytokines, cluster, predictors
AB Purpose: To characterize and predict the clinical and tear molecular response ofcontact lens (CL) wearers exposed to a controlled adverse desiccatingenvironment (CADE).Methods: Objective and subjective variables and tear cytokine levels of monthlysilicone hydrogel CL wearers were evaluated pre- and post-90 min of CADEexposure. Unsupervised hierarchical agglomerative clustering based on relativechange from baseline values was used to identify response profiles (clusters). Amultiple logistic regression model was used to identify cluster membershippredictors.Results: Forty-seven CL wearers were divided into 3 clusters having similar age(mean: 27.7±7.7 years) and sex proportion. All of them showed a significant(p≤0.05) increase in limbal hyperemia and staining after CADE exposure.Additionally, Cluster-1 (n=22, 46.8%) membership was characterized by asignificant (p≤0.05) higher worsening of corneal and limbal staining, increasedCL wear symptoms, and reduced epidermal-growth-factor and increasedinterleukin (IL)-4 and IL-6 tear levels. Cluster-2 (n=22, 46.8%) showed nochanges (p>0.05) in symptoms after CADE; however, their IL-12p70, monocytechemoattractant-protein-1 and regulated-on-activation, normal-T-cell-expressedand-secreted (RANTES) post-exposure tear levels significantly (p≤0.05)increased. Finally, Cluster-3 (n=3, 6.4%) mainly showed significant higher blinkrate (78.1±21.7) during CADE. Corneal staining and tear IL-12p70 levels wereidentified as Cluster-1 membership predictors.Conclusions: Most of silicone hydrogel CL wearers exposed to CADE showeda worsening of the ocular surface and an upregulated tear inflammatory status.However, only half of them reported worsening of CL wear symptoms. These CLwearers were detected based on corneal integrity and tear inflammatory status.These findings can help reduce CL use discontinuation and drop out.
PB Elsevier
SN 1542-0124
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/72726
UL https://uvadoc.uva.es/handle/10324/72726
LA eng
NO Ocular Surface, 2020;18:829-840
NO Producción Científica
DS UVaDOC
RD 26-dic-2024