RT info:eu-repo/semantics/article
T1 Multibranched Gold–Mesoporous Silica Nanoparticles Coated with a Molecularly Imprinted Polymer for Label-Free Antibiotic Surface-Enhanced Raman Scattering Analysis
A1 Carrasco, Sergio
A1 Benito-Peña, Elena
A1 Navarro-Villoslada, Fernando
A1 Langer, Judith
A1 Sanz-Ortiz, Marta N.
A1 Reguera, Javier
A1 Liz-Marzán, Luis M.
A1 Moreno-Bondi, María C.
AB We describe the preparation of multibranched gold−silica−molecularly imprinted polymer (bAu@mSiO2@ MIP) core−shell nanoparticles, with their specific ability to recognize enrofloxacin (ENRO), and their application as label- free nanosensors for the specific detection of the antimicrobial by surface-enhanced Raman scattering. The use of these nanocomposites results in a large enhancement of the Raman scattering of ENRO upon binding of an antibiotic to the selective recognition sites in the MIP. These are in the proximity of the gold core branches that act as intrinsic hot spots providing highly localized and strongly enhanced electromagnetic fields caused by plasmon resonance. The effect of the multibranched morphology of the gold cores (bAu) on the optical spectroscopic response of the bAu@mSiO2@MIP nanosensors is investigated with the aim of improving ENRO detection. The optimized nanostructures allowed us to achieve a detection limit of 1.5 nM for ENRO, which is 2 orders of magnitude lower than those for previously reported Au@MIP nanosensors, additionally providing negligible cross-reactivity toward other potential interfering species.
PB ACS
SN 0897-4756
YR 2016
FD 2016
LK https://uvadoc.uva.es/handle/10324/73038
UL https://uvadoc.uva.es/handle/10324/73038
LA spa
NO Chem. Mater. 2016, 28 (21) 7947–7954
NO Producción Científica
DS UVaDOC
RD 08-ene-2025