RT info:eu-repo/semantics/article
T1 Guyparkeria halophila: Novel cell platform for the efficient valorization of carbon dioxide and thiosulfate into ectoine
A1 Huang-Lin, Elisa
A1 Tamarit, Daniel
A1 Lebrero Fernández, Raquel
A1 Cantera Ruiz De Pellon, Sara
K1 Chemolithoautotrophs
K1 CO2 bioconversion
K1 Fine chemicals
K1 Thiosulfate oxidation
AB Utilizing carbon dioxide (CO2) for valuable chemical production is key to a circular economy. Current processes are costly due to limited microorganism use, low-value products, and the need for affordable energy. This study addresses these challenges by using industrial contaminants like thiosulfate (S2O32−) for CO2 conversion into ectoines. Ectoines, are important ingredients as pharmaceuticals and cosmetics. Here, six microbial genomes were identified as potential candidates to valorize CO2 and S2O32− into ectoine. After laboratory validation at 3 % NaCl, the fastest-growing strain, Guyparkeria halophila, was optimized at 6 %, 9 %, and 15 % NaCl, showing the highest specific ectoine contents (mgEct gbiomass−1) at 15 %. Batch bioreactors, combining optimal conditions, achieved maximum specific ectoine contents of 47 %. These results not only constitute the highest ectoine content so far reported by autotrophs and most of heterotrophs, but also the first proof of a novel valorization platform for CO2 and S2O32−, focused on pharmaceuticals production.
PB Elsevier
SN 0960-8524
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/73255
UL https://uvadoc.uva.es/handle/10324/73255
LA eng
NO Bioresource Technology, septiembre 2024, vol. 408, 131152
NO Producción Científica
DS UVaDOC
RD 05-feb-2025